Evidence map›Paper›PMID 40525125›Full record

ArticleMolecular therapy. Methods & clinical development2025

Common AAV gene therapy vectors show nonselective transduction of

J P McGinnis, Joshua Ortiz-Guzman, Maria Camila Guevara, Sai Mallannagari, Benjamin D W Belfort, Suyang Bao, Snigdha Srivastava, Maria Morkas, Emily Ji, Angela Addison and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

J P McGinnisDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Joshua Ortiz-GuzmanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Maria Camila GuevaraDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Sai MallannagariDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Benjamin D W BelfortDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Suyang BaoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Snigdha SrivastavaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Maria MorkasDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Emily JiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Angela AddisonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Evelyne K TantryDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Sarah ChenJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Ying WangJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Zihong ChenJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Kalman A KatlowitzDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Jeffrey J LangeStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Melissa M BlessingDepartment of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
Carrie A MohilaDepartment of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
M Cecilia LjungbergJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Guillermo AldaveDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Ali JalaliDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Akash PatelDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Howard L WeinerDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Shankar GopinathDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Ganesh RaoDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Akdes Serin HarmanciDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Daniel J CurryDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Benjamin R ArenkielDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Single Cell Spatial Transcriptomics Shared Instrument at the BCM Core FacilityS10OD032189 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2022 to 2022
$304k
Tecan EVO GenePaint robotS10OD016167 · OD · BAYLOR COLLEGE OF MEDICINE · PI LJUNGBERG, CECILIA · 2013 to 2013
$215k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NICHD NIH HHS P50 HD103555NIH HHS S10 OD016167NIH HHS S10 OD032189
6 · The paper itself

Abstract

The ability to deliver a therapeutic sequence to a specific cell type in the human brain would make possible innumerable therapeutic options for some of our most challenging diseases; however, studies on adeno-associated virus (AAV) vector tropism have generally relied on animal models with limited translational utility. For this reason, establishing the tropism of common adeno-associated virus (AAV) vectors in living human brain tissue serves as an important baseline for further optimization, as well as a determination of human brain cell types transduced by clinically approved gene therapy vectors AAV2 and AAV9. We have adapted an

Indexed as

AAVAAV tropismgene therapyhuman brainhuman brain organotypic slice culture

Identifiers

PMID40525125
PMCPMC12169722

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.