ArticleCureus2025
Sporadic Coexistence of Parathyroid Adenoma, Papillary Thyroid Carcinoma, Pheochromocytoma, and Cardiac Myxoma: A Multidisciplinary Approach to an Extremely Rare Tumor Constellation.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 74-year-old woman was referred for evaluation of asymptomatic hypercalcemia detected during a routine health examination. Laboratory testing confirmed primary hyperparathyroidism, with elevated serum calcium and intact parathyroid hormone (PTH) levels. Further diagnostic workup revealed a constellation of neoplasms: a parathyroid adenoma, papillary thyroid carcinoma, a right adrenal pheochromocytoma, a non-functional left adrenal cortical adenoma, and an incidental left atrial myxoma. There was no family history suggestive of hereditary tumor syndromes, and the patient declined genetic testing despite medical recommendation. A multidisciplinary team, including specialists in endocrinology, urology, otolaryngology, cardiology, cardiovascular surgery, and anesthesiology, collaborated to formulate a treatment strategy that minimized perioperative risks. Given the risk of hypertensive crisis, the right adrenal pheochromocytoma was resected first following adequate alpha-adrenergic blockade. This was followed by parathyroidectomy and left thyroid lobectomy with central neck dissection. Finally, to prevent potential embolic complications, the left atrial myxoma was excised via a transseptal approach under cardiopulmonary bypass. Histopathological examination confirmed the diagnoses of all tumors, with no evidence of malignant transformation or residual disease. This case illustrates a rare constellation of endocrine and cardiac tumors. Although the presentation raised clinical suspicion for hereditary syndromes such as multiple endocrine neoplasia (MEN) or Carney complex, the patient's advanced age, absence of mucocutaneous features, and negative family history favored a sporadic etiology. Nonetheless, the unusually delayed onset raises the possibility of a low-penetrance or as-yet-undescribed hereditary syndrome. Strategic surgical sequencing and interdisciplinary coordination were critical to ensuring patient safety and favorable clinical outcomes. Lifelong follow-up remains essential to monitor for recurrence and to reassess genetic risks as genomic technologies continue to evolve.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.