ArticleCureus2025
Face the Pain: Radiobiological and Clinical Considerations of Re-radiosurgery to the Trigeminal Nerve Following Irradiation of an Abutting Petroclival Meningioma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Trigeminal neuralgia is a common symptom of benign tumors compressing the trigeminal nerve, leading to debilitating pain and a devastating impact on quality of life. Stereotactic radiosurgery is a validated option for intracranial meningiomas with excellent tumor control rates that correlate with symptomatic improvement. Select cases with refractory or recurrent trigeminal neuralgia can benefit from a second treatment targeting the trigeminal nerve. We present a case of refractory trigeminal neuralgia secondary to compression of a previously irradiated petroclival meningioma successfully treated with a second radiosurgery course targeting cranial nerve V (CN V). Multidisciplinary considerations, patient-centered factors, radiobiological considerations, and technical challenges faced in the intracranial reirradiation setting when cumulative dose constraints are previously met or exceeded are discussed.
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