Evidence map›Paper›PMID 40524929›Full record

ArticleERJ open research2025

Wasted ventilation in mild COPD: protocol for a clinical physiology and functional imaging study.

Matthew D James, Andreas Voskrebenzev, Filip Klimeš, Brandon Zanette, Karam Alosta, Abed A Hijleh, Sandra G Vincent, Nicolle J Domnik, Devin B Phillips, Marina Pourafkari and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Matthew D JamesRespiratory Investigation Unit, Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0003-1586-6897
Andreas VoskrebenzevInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Filip KlimešInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Brandon ZanetteTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Karam AlostaRespiratory Investigation Unit, Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada.
Abed A HijlehRespiratory Investigation Unit, Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada.
Sandra G VincentRespiratory Investigation Unit, Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada.
Nicolle J DomnikRespiratory Investigation Unit, Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0001-6883-4720
Devin B PhillipsSchool of Kinesiology and Health Science, York University, Toronto, ON, Canada.
Marina PourafkariDepartment of Diagnostic Radiology, Queen's University, Kingston, ON, Canada.
Chu-Yi WangThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Michele GirardiThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID https://orcid.org/0000-0001-8102-7384
Carrie FergusonThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Miranda KirbyDepartment of Physics, Toronto Metropolitan University, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-2951-784X
Giles SantyrTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
William StringerThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Janos PorszaszThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Denis E O'DonnellRespiratory Investigation Unit, Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0001-7593-2433
Jens Vogel-ClaussenInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
J Alberto NederRespiratory Investigation Unit, Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0002-8019-281X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: High ventilation-CO Central hypothesis: Increased areas of high alveolar ventilation ( Methods: 40 patients (20 women) showing post-bronchodilator forced expiratory volume in 1 s ≥70% predicted and 20 sex- and age-matched controls will perform constant load exercise tests in a flutter-kicking device in the physiology laboratory and, in another visit, a magnetic resonance imaging (MRI) facility. Volumetric capnography will be used to breath-by-breath quantify rest and exercise Study implications: Confirmation of the study's main hypothesis will provide the first evidence that increased wasted ventilation in dyspnoeic patients with mild COPD is not a mere consequence of emphysematous destruction being also reflective of impaired perfusion across apparently preserved lung tissue. This will set the stage for subsequent interventional studies geared to address this potentially treatable disease trait.

Identifiers

PMID40524929
PMCPMC12168168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.