ArticleCurrent research in food science2025
The effect of Gougunao tea polysaccharide on lipid metabolism in hyperlipidemia induced by a high-fat diet and its structural characteristics.
Article in Current research in food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Metabolomics-Based Elucidation of the Lipid-Lowering Mechanisms ofFoods (Basel, Switzerland) · 2026Article
- L-Theanine ameliorates high-protein diet-associated hepatic glucose and lipid metabolic alterations by promoting fatty acid β-oxidation and suppressing lipid synthesis and gluconeogenesis in rats.Current research in food science · 2026Article
- Causal Effects of Diet on Atopic Dermatitis: A Mendelian Randomization Study Implicating Lipid Pathways and Clinical Implications.Clinical, cosmetic and investigational dermatology · 2026Article
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9 authors.
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Abstract
In this study, the effect of Gougunao tea polysaccharide (GTP40) on lipid metabolism in high-fat diet (HFD)-induced hyperlipidemic mice and its core structure were investigated. GTP40 effectively reversed the increase in weights of the liver and adipose tissues induced by HFD. The oxidative stress of the liver was also significantly alleviated following GTP40 intervention. According to the results of Real-Time quantitative Polymerase Chain Reaction (RT-qPCR), the genes associated with lipolysis were upregulated after GTP40 treatment, while lipogenesis-related genes were downregulated. Additionally, a homogeneous polysaccharide (GTP40-5P, obtained by degrading GTP40 for 5 h) with a molecular weight of 27858 Da was fractionated from GTP40 by the partial acid hydrolysis method. GTP40-5P was mainly composed of 62.30 ± 0.70 % neutral sugar, 54.82 ± 0.51 % uronic acid and 2.52 ± 0.74 % protein. The results of methylation and nuclear magnetic resonance (NMR) analysis indicated that the backbone of GTP40-5P was consisted of →4)-
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