Evidence map›Paper›PMID 40524908›Full record

ArticleBioinorganic chemistry and applications2025

Enhancing Polyphenol Delivery and Efficacy Using Functionalized Gold Nanoparticles: Antioxidant and Antibacterial Properties.

Siham Bouaouz, Miriam Chavez, Cornelia E Peña González, Daniel Rojas, Alberto Escarpa, Paula Ortega, F Javier de la Mata

Abstract read
In one paragraph

Article in Bioinorganic chemistry and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siham BouaouzDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcala, Madrid, Spain.ORCID https://orcid.org/0000-0002-0640-9822
Miriam ChavezDepartment of Analytical Chemistry, Physical Chemistry and Chemical Engineering, Institute in Chemistry "Andrés M. del Río" (IQAR) University of Alcala, Madrid, Spain.ORCID https://orcid.org/0000-0002-5512-7485
Cornelia E Peña GonzálezDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcala, Madrid, Spain.ORCID https://orcid.org/0000-0002-9049-8804
Daniel RojasDepartment of Analytical Chemistry, Physical Chemistry and Chemical Engineering, Institute in Chemistry "Andrés M. del Río" (IQAR) University of Alcala, Madrid, Spain.ORCID https://orcid.org/0000-0002-4404-4668
Alberto EscarpaDepartment of Analytical Chemistry, Physical Chemistry and Chemical Engineering, Institute in Chemistry "Andrés M. del Río" (IQAR) University of Alcala, Madrid, Spain.ORCID https://orcid.org/0000-0002-7302-0948
Paula OrtegaDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcala, Madrid, Spain.ORCID https://orcid.org/0000-0003-0377-5429
F Javier de la MataDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcala, Madrid, Spain.ORCID https://orcid.org/0000-0003-0418-3935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research into the use of nanoparticles to enhance the delivery and efficacy of polyphenols is a topic of growing interest in the fields of nanotechnology, pharmacology and food science. Nanoparticles, due to their small size and high surface area, can improve the stability, solubility and bioavailability of polyphenols. Combining polyphenols with other bioactive compounds within nanoparticles can create synergistic effects, enhancing their overall therapeutic potential. In this work, we present a new polyethylene glycol (PEG) capping ligand modified with caffeic acid (CA), HS-PEG-CA and two types of gold nanoparticles: (i) coated with a PEG-thiol derivative functionalized with CA (HS-PEG-CA) (homofuncionalized NP) and (ii) HS-PEG-CA cationic carbosilane dendrons with antibacterial properties (heterofuncionalized NP). The antioxidant capacity of the CA, in three systems, has been studied by different techniques such as FRAP, DDPH and cyclic voltammetry, demonstrating that it is preserved when it is supported on the NP and increases when it is part of the PEG ligand. In addition, heterofuntionalized NP showed activity against

Indexed as

antibacterialantioxidantdendrongold nanoparticles

Identifiers

PMID40524908
PMCPMC12170072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.