ArticleNature and science of sleep2025
Alterations on Microcirculation of Optic Nerve Head Before and After OSA Surgery.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Objective: Obstructive sleep apnea/hypopnea syndrome (OSA) can compromise oxygenation of the optic nerve and cause glaucomatous optic neuropathy; however, there were no studies to investigate the changes of optic nerve microcirculation in patients with OSA before and after treatment. We conducted the first study to assess whether OSA surgery will change the optic nerve microcirculation in patients with OSA. Study Design: Prospective single-blind study. Setting: Tertiary medical center. Methods: The enrolled patients were completed for overnight polysomnography (PSG) and comprehensive ophthalmologic evaluation, including laser speckle flowgraphy (LSFG) for microcirculation of optic nerve head (ONH) before and 3 months after OSA surgery. LSFG measurements were summarized as mean blur rate in all areas (MA), in big vessel area (MV) and in tissue area (MT) of ONH. Results: Twenty-nine patients underwent upper airway surgery were included. Three months after surgery, 75.9% (22/29) patients, including 15 of 20 patients with severe OSA and 7 of 9 patients with moderate OSA had improvement in apnea/hypopnea index (AHI). The major parameters of PSG significantly improved. Regarding the LSFG parameters, MA ( Conclusion: The ONH microcirculation significantly improved in the AHI-improved patients with OSA 3 months after upper airway surgery. Upper airway surgery may ameliorate the ONH microcirculation in patients with OSA.
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