ArticleDrug design, development and therapy2025
Drug Interaction Potential of Berberine Hydrochloride When Co-Administered with Tofacitinib and Filgotinib in Rats.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Preparation of colon-targeted pellets loaded with filgotinib/berberine hydrochloride and Their application in ulcerative colitis therapy.International journal of pharmaceutics: X · 2025Article
- Natural metabolites used in traditional Chinese medicine for cardiovascular diseases: pharmacological mechanisms, evidence, and future directions.Frontiers in pharmacology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisticated in terms of mechanism. However, no studies have yet explored their interactions. This study aimed to establish a highly sensitive, specific, and reproducible HPLC-MS/MS method for investigating the pharmacokinetic interactions between BBR-TOFA and BBR-FIGA in rats. Methods: The analytes and internal standards were extracted from rat plasma using a mixed solvent of dichloromethane and ether (3:2 ratio). The mobile phase comprised a mixture of methanol (containing 0.1% formic acid) and water (containing 0.1% formic acid and 2 mm ammonium acetate), with a flow rate of 0.6 mL/min. Elution was performed in a gradient mode on a Phenomenex Kinetex column (50×3.0 mm, 2.6 μm). A systematic methodological validation was conducted according to the standards of the Chinese Pharmacopoeia, covering aspects such as specificity, calibration curve and linearity, residual effects, precision and accuracy, recovery, matrix effect, dilution integrity, and stability. Results: All methodological validation parameters met the standards of the Chinese Pharmacopoeia, confirming the method's suitability for simultaneously determining the concentrations of BBR, TOFA, and FIGA in rat plasma. Pharmacokinetic experimental results indicate that TOFA and FIGA have no significant effect on the plasma concentration of BBR across various pharmacokinetic parameters. However, due to BBR's inhibition or induction of various drug-metabolizing enzymes, it significantly affects some of the pharmacokinetic parameters of TOFA and FIGA.
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