ArticleJournal of oral microbiology2025
Association of supragingival plaque management with subgingival microbiota is moderated by adjunctive antibiotics in stage III-IV periodontitis patients during periodontal therapy.
Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Exhaled Carbon Monoxide Indicates Persistent Subgingival Dysbiosis After Periodontal Therapy.Journal of clinical periodontology · 2026Article
- SANA-Biome: A Protocol for a Cross-Sectional Study on Oral Health, Diet, and the Oral Microbiome in Romania.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study examines the relationship between supragingival plaque control and subgingival microbiota during periodontal therapy, focusing on microbial clusters associated with plaque levels. Methods: Data were drawn from a 26-month multicenter, double-blinded, randomized, placebo-controlled trial. Supragingival plaque was measured using the O'Leary index, and subgingival microbiota were profiled via Illumina 16S rRNA gene sequencing. A novel topic modelling approach using cross-validated Latent Dirichlet Allocation (LDA) identified microbial clusters, and negative binomial mixed models evaluated their association with plaque levels. Results: Supragingival plaque was positively associated with bleeding on probing (BOP) and microbial diversity, but not with dysbiosis. A specific subgingival microbial cluster dominated by Conclusion: Ineffective supragingival plaque control correlates with increased BOP and microbial diversity, though not necessarily with dysbiosis. Adjunctive antibiotics may promote a more cariogenic subgingival microbiota by disrupting the association between plaque accumulation and the abundance of acidogenic taxa such as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.