Evidence map›Paper›PMID 40524692›Full record

ReviewNeurobiology of stress2025

Building a social brain: Cells, circuits and behavior across the lifespan.

Maya Opendak

Abstract readReview
In one paragraph

Review in Neurobiology of stress, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Maya OpendakKennedy Krieger Institute, Baltimore, MD, 21205, USA.

Funding

Identifying a role for the lateral habenula in typical and perturbed social behavior developmentR01MH133456 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Maya Opendak · 2023 to 2026
$1.6M
Neurobiology of Social Behavior: Circuit Analysis in Early LifeR00MH124434 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI OPENDAK, MAYA · 2022 to 2024
$961k
NIMH NIH HHS R00 MH124434NIMH NIH HHS R01 MH133456
6 · The paper itself

Abstract

Disrupted social behavior is a fundamental indicator of compromised mental health, such as anxiety and depression, and serves as an early diagnostic marker for disorders that can develop later in life. However, our understanding of how the neural circuits for social behavior develop and how environmental disturbances at various developmental stages affect infant behavior is limited. Through my research with rats, I have established a foundation for identifying specific neuroanatomical circuits in infants that produce age-appropriate social behavior and how these systems may change in response to adversity. Overall, these studies have helped generate technical and conceptual advances in our understanding of social development and early life stress. These studies have employed multiple levels of analysis and functional brain dissection to identify novel targets of early social stress and measure how the infant brain responds to social information in typical and perturbed development.

Indexed as

AmygdalaDevelopmentDopamineHabenulaSocial behaviorStress

Identifiers

PMID40524692
PMCPMC12168214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.