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ArticleEuropean urology open science2025

Prevalence and Prognostic Significance of Preoperative Anemia in Radical Cystectomy Patients: A Multicenter Retrospective Observational Study.

Ernest Kaufmann, Luca Antonelli, Luca Afferi, Vincenzo Asero, Francesco Prata, Silvia Rebuffo, Alessandro Veccia, Meftun Culpan, Karl Tully, Luis Ribeiro and 24 more

Abstract read
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In one paragraph

Article in European urology open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Ernest KaufmannDepartment of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland.
Luca AntonelliDepartment of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland.
Luca AfferiDepartment of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland.
Vincenzo AseroDepartment of Urology, Sapienza University of Rome, Rome, Italy.
Francesco PrataDepartment of Urology, Fondazione Policlinico Universitario Campus BIo-Medico of Rome, Rome, Italy.
Silvia RebuffoIRCCS Ospedale Policlinico S. Martino, Genoa, Italy.
Alessandro VecciaDepartment of Urology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Meftun CulpanDepartment of Urology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Karl TullyDepartment of Urology and Neurourology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
Luis RibeiroSt. George's University Hospital, London, UK.
Thierry RoumeguereService d'Urologie, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Bruxelles, Belgium.
Kees HendricksenDepartment of urology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Luca LambertiniUnit of Oncologic Minimally Invasive Urology and Andrology - Careggi Hospital, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
Renate PichlerDepartment of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Nicola PavanUrology Clinic, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo, Italy.
Jeremy Yuen-Chun TeohS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Mathieu RoumiguiéDepartment of Urology, CHU-IUCT, Toulouse, France.
Gerald Bastian SchulzDepartment of Urology, LMU Munich, Munich, Germany.
Francesco SoriaDivision of Urology, Department of Surgical Sciences, AOU città della Salute e della Scienza di Torino, Torino School of Medicine, Torino, Italy.
Aamer AlGhamlasUrology, GRC 5 Predictive Onco-Uro, AP-HP, Pitie-Salpetriere Hospital, Sorbonne University, Paris, France.
Pierre-Emmanuel DesprezUrology Department, Claude Huriez Hospital, CHU Lille, Lille, France.
Luca OrecchiaUrology Unit, Department of Surgical Sciences, Tor Vergata University Hospital, University of Rome Tor Vergata, Rome, Italy.
Cedric PoyetDepartment of Urology, Stadtspital Zürich Triemli, Zürich, Switzerland.
Majed AlrumayyanDivision of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Michael RinkDepartment of Urology, Marienkrankenhaus Hamburg, Hamburg, Germany.
Stefania ZamboniUnit of Urology, Department of Medical and Surgical Specialities, Radiological Science and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Maria Riaza MontesGaldakao-Usansolo Hospital, Vizcaya, Spain.
Steven OkoyeDepartment of Urology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Mattia Lo ReUnit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy.
Wojciech KrajewskiDepartment of Minimally Invasive and Robotic Urology, Wrocław Medical University, Wrocław, Poland.
Luke LavalleeDivision of Urology, Department of Surgery, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Marian Severin WettsteinDepartment of Uro-Oncology, University of Toronto, Toronto, ON, Canada.
Marco MoschiniDepartment of Urology and Division of Experimental Oncology, Urological Research Institute, Vita-Salute San Raffaele, Milan, Italy.
Christian Daniel FankhauserDepartment of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: Preoperative anemia is common in patients undergoing radical cystectomy for bladder cancer, but its prevalence and impact on outcomes remain poorly characterized across different health care settings. This study aims to assess the prevalence of preoperative anemia, evaluate its current management practices, and determine its association with postoperative and oncological outcomes in patients undergoing radical cystectomy. Methods: We retrospectively analyzed 4886 patients with nonmetastatic bladder cancer who underwent radical cystectomy across 28 centers in 13 countries. Multivariable regression models identified the predictors of preoperative hemoglobin levels and postoperative blood transfusions. Survival outcomes were assessed using Kaplan-Meier and Cox proportional hazards regression analyses. Key findings and limitations: Preoperative anemia was present in 44% of women and 48% of men. Among anemic patients, 73% received no blood management interventions. Higher hemoglobin levels before transurethral resection of a bladder tumor correlated with higher levels before cystectomy and fewer postoperative blood transfusions (odds ratio: 0.98, 95% confidence interval [CI]: 0.97-0.99, Conclusions and clinical implications: Preoperative anemia is prevalent and undertreated in patients undergoing radical cystectomy, and is independently associated with adverse perioperative and oncological outcomes. This highlights the need for further research regarding the potential benefits of implementing systematic preoperative anemia management. Patient summary: This study found that low blood counts before bladder removal surgery are common, often untreated, and linked to worse outcomes. Early treatment of low blood counts before surgery could improve results for patients.

Indexed as

AnemiaBladder cancerHemoglobinPatient blood managementRadical cystectomySurvival outcomes

Identifiers

PMID40524687
PMCPMC12169704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.