ArticleJournal of veterinary internal medicine
Long-Term Clinical Response to Medical Treatment, Behavioral Therapy, or Their Combination in Cats With Hyperesthesia Syndrome.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A presumptive diagnosis of feline hyperesthesia syndrome due to stressful human-related condition: case report.Veterinary research communications · 2026Article
- Retrospective Analysis of Compulsive-like Long-Standing Unacceptable Urination in Cats.Veterinary sciences · 2026Article
- Long-Term Clinical Response to Medical Treatment, Behavioral Therapy, or Their Combination in Cats With Hyperesthesia Syndrome.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperesthesia syndrome (HS) is a common yet poorly understood condition in cats, with hypothesized neurological and behavioral causes and limited data on outcomes and treatment.
objectivesThis study aimed to describe the clinical outcomes and the treatment response of 28 cats with HS, managed through various therapeutic strategies. ANIMALS: Clinical records of 28 cats with HS and minimum of 1-year follow-up were reviewed.
methodsRetrospective, observational, descriptive study conducted on a case series of cats affected by HS. Sixteen cats (57%) received fluoxetine alone (Fluoxetine-only), seven (25%) were managed with behavioral modification and gabapentin or fluoxetine (Fluoxetine/Gabapentin + Behavior) and five (18%) were treated with behavioral modification alone (Behavior-only).
resultsAn episode-free period (EFP) ≥ 9 months was observed in 23 (82%) cats. Fifteen cats (94%) in the Fluoxetine-only group experienced an EFP of ≥ 9 months. Moreover, they had a shorter time to recovery (median [IQR] = 8 [3.5-18] days) compared to the Fluoxetine/Gabapentin + Behavior and Behavior-only groups (median [IQR] = 100 [90-210] and 60 [30-90] days, respectively). At the 1-year follow-up, 26 (93%) cats no longer had HS clinical signs and 14 (50%) were still under pharmacotherapy. Relapses were reported only in one case (4%).
conclusionsMost of the cat's diagnosed with HS, and managed through various therapeutic strategies, experienced an EFP of more than 9 months and showed absence of clinical signs at 1 year follow-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.