Evidence map›Paper›PMID 40524639›Full record

Trial reportAnaesthesiology intensive therapy2025

Intranasal dexmedetomidine versus intranasal midazolam as a standard of care for pediatric patients undergoing transcatheter perimembranous ventricular septal defect (VSD) closure: a randomized controlled trial.

Mohammed Saed Shorbagy, Ramy Mahrose, Amr A Kasem, Yasmin Abdelrazik Ali, Sally Hamdy Abdelaziz

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Anaesthesiology intensive therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammed Saed ShorbagyDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ramy MahroseDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Amr A KasemDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Yasmin Abdelrazik AliDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Sally Hamdy AbdelazizDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSedative premedication may hold notable significance in pediatric patients undergoing diagnostic and interventional cardiac catheterization, as it minimizes anxiety, facilitates parental separation, and allows for the acceptance of inhalational induction. The intranasal route is a reliable method for administering sedatives as pre- medication in pediatric patients. This study compared and evaluated the sedative effects of intranasal dexmedetomidine versus intranasal midazolam as premedication in pediatric patients undergoing transcatheter closure of ventricular septal defects. MATERIAL AND

methodsThis prospective, randomized, double-blind study included 40 pediatric patients aged 3 to 6 years scheduled for transcatheter perimembranous VSD closure under general anesthesia. The subjects were randomly assigned to receive either intranasal midazolam at 0.2 mg kg

resultsThis study included 40 individuals with similar demographic profiles and comparable duration of the procedure (

conclusionsPediatric patients were successfully and effectively sedated with both intranasal dexmedetomidine and intranasal midazolam, with stable hemodynamics and oxygen saturation.

Indexed as

Cardiac CatheterizationDexmedetomidineHeart Septal Defects, VentricularHypnotics and SedativesMidazolamAdministration, IntranasalChildChild, PreschoolDouble-Blind MethodFemaleHumansMaleProspective StudiesDexmedetomidineHypnotics and SedativesMidazolamintranasal dexmedetomidineintranasal midazolampremedicationventricular septal defect (VSD)

Identifiers

PMID40524639
PMCPMC12210370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.