Evidence map›Paper›PMID 40524570›Full record

ArticleThe British journal of nutrition2025

Metabolomics profiling of hypervitaminosis A in South African preschoolers is characterised by modified serum lysophospholipids and oxylipins.

Rairaja Cohen, Jesse Sheftel, Jennifer Luevano, Meredith O Kelly, Rob K Fanter, Martha E van Stuijvenberg, Muhammad A Dhansay, Alex Brito, Sherry A Tanumihardjo, Michael R La Frano

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In one paragraph

Article in The British journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rairaja CohenDepartment of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, CA, USA.
Jesse SheftelUniversity of Wisconsin-Madison, Madison, WI, USA.
Jennifer LuevanoDepartment of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, CA, USA.
Meredith O KellyCal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, CA, USA.
Rob K FanterCollege of Agriculture, Food and Environmental Sciences, California Polytechnic State University, San Luis Obispo, CA, USA.
Martha E van StuijvenbergNon-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
Muhammad A DhansayDivision of Human Nutrition, Department of Global Health, Stellenbosch University, Cape Town, South Africa.
Alex BritoSchool of Nutrition and Dietetics, Faculty of Rehabilitation and Quality of Life Sciences, Universidad San Sebastián, Patagonia Campus, Puerto Montt, Chile.ORCID https://orcid.org/0000-0002-6212-8814
Sherry A TanumihardjoUniversity of Wisconsin-Madison, Madison, WI, USA.
Michael R La FranoDepartment of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, CA, USA.ORCID https://orcid.org/0000-0002-2269-1688

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence indicates hypervitaminosis A may be attributed to overconsumption of natural preformed vitamin A (VA) and overlapping VA intervention strategies. Hypervitaminosis A can disrupt metabolic processes; however, the extent and mechanisms of these impacts are not well understood. This study aims to assess metabolic differences related to hypervitaminosis A and VA supplementation by performing metabolomics analysis. A subsample of South African preschoolers participating in the country's VA supplementation programme was selected. Participants were divided into two groups: adequate VA (

Indexed as

Hypervitaminosis ALysophospholipidsMetabolomicsOxylipinsVitamin AChild, PreschoolDietary SupplementsFemaleHumansLipidomicsMaleSouth AfricaLysophospholipidsOxylipinsVitamin AHypervitaminosis ALipidomicsNutritional metabolomicsOxylipinsPreschoolersSouth AfricaVitamin A

Identifiers

PMID40524570
PMCPMC12303720

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.