ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Association of environmental exposome and cognitive function among older adults with and without preclinical Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Exposome-wide association study and predictive risk score for incident Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Exploring the associations between lifestyle and dietary patterns with preclinical alzheimer's disease: findings from La Rioja cohort study.European journal of nutrition · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- From cradle to cortex: An exposome- and equity-centered perspective of neurocognitive aging and dementia risk in the era of climate change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- Oxidative Stress and Lysosomal Dysfunction in Neurodegenerative Diseases: Underlying Mechanisms and Nanotherapeutic Targeting Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.Nature aging · 2026Review
- Predicting low premorbid cognitive ability with social determinants: A machine learning approach.JAR life · 2026Article
- Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study.Neuroepidemiology · 2025Article
- Association of environmental exposome and cognitive function among older adults with and without preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
introductionSociodemographic predictors are established risk factors for Alzheimer's disease (AD), a leading cause of cognitive decline. This study examines the influence of environmental exposures like walkability, green space, and light pollution among older adults.
methodsCross-sectional analysis examined associations between walkability, green space, tree canopy, light pollution, and cognitive functioning among participants with and without preclinical AD based on cerebrospinal fluid (CSF) and/or positron emission tomography (PET) biomarkers. Generalized additive mixed models (GAMMs) assessed their impact on cognitive performance, controlling for sex and race as categorical covariates, with age and education included as continuous variables modeled using smooth functions.
resultsWalkability, green space, and tree canopy were significantly associated with better cognitive performance, while light pollution negatively impacted cognition. Biomarker positivity was not a significant predictor. DISCUSSION: Our findings highlight the crucial role of environmental exposures on cognition, suggesting that urban design and environmental quality influence cognitive trajectories in older adults, regardless of biomarker status. HIGHLIGHTS: Walkability, green space, and tree canopy improve cognitive performance. Light pollution is linked to lower cognitive function in older adults. Biomarker positivity was not a significant predictor of cognitive outcomes. Urban design plays a key role in cognitive health and Alzheimer's risk.
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