ArticleMolecular plant pathology2025
A Toxin of Valsa mali Determines Virulence and Host Preference.
Article in Molecular plant pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A functional atlas of secondary metabolite biosynthetic gene clusters governing growth, stress adaptation, and pathogenicity in Fusarium graminearum.Crop health · 2026Article
- Transcriptome sequencing reveals Vmplc1 involved in regulating the pathogenicity of Valsa Mali under low temperature induction.BMC genomics · 2025Article
- A Toxin of Valsa mali Determines Virulence and Host Preference.Molecular plant pathology · 2025Article
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Authors and funding
8 authors.
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Abstract
Through co-evolutionary adaptation, phytopathogenic fungi have evolved specialised host preference mechanisms to optimise infection efficacy. Fungi of the Valsa genus infect various Rosaceae fruit trees, with Valsa mali exhibiting a marked host preference for apple trees, while Valsa pyri preferentially colonises pear trees. The divergent secondary metabolite biosynthetic gene clusters (SMBGCs) between these two species may serve as key determinants of their distinct host preferences. In this study, VmPKS5, a polyketide synthase, was identified as a key factor influencing the host preference of V. mali, which is the main pathogen of apple Valsa canker (AVC). Deletion of VmPKS5 greatly reduced the virulence of V. mali in apple trees, but not in pear trees. Deletion of VmPKS5 completely abolished the production of the toxin p-coumaric acid ethyl ester (p-CAEE). Exogenous p-CAEE application partly restored the virulence of ΔVmPKS5 and enhanced the virulence of the wild-type strain of V. mali. Crucially, heterologous expression of VmPKS5 in V. pyri increased its virulence towards apple trees by production of p-CAEE during infection. Notably, V. mali can uptake double-stranded RNA (dsRNA), and exogenous spray of VmPKS5-dsRNA significantly inhibited the infection by V. mali. This study provides new perspectives on host preference mechanisms of fungal pathogens and green disease control of tree disease by dsRNA fungicides.
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