Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Effect of Neibu Huangqi Youhua formula on postoperative wound healing, inflammatory factors and pain mediators of anal fistula.
Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effect of Huiyang Shengji unguent on the NOD-like receptor family pyrin domain containing protein 3/caspase1/ gasdermin D pathway and lymphatic angiogenesis in patients with diabetic foot ulcer.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Trial
- Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway.Frontiers in immunology · 2025Article
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Authors and funding
4 authors.
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Abstract
objectiveTo explore the clinical efficacy of the Chinese medicine, Neibu Huangqi Youhua formula combined with Kangfuxin solution for the nursing of patients after anal fistula surgery.
methodsA total of 160 cases with anal fistula who underwent surgical treatment were recruited, and divided into control group (treated with external application of Kangfuxin liquid gauze) and experimental group (receiving the Neibu Huangqi Youhua formula combined with Kangfuxin liquid gauze) based on a random numbering table. The wound recovery, postoperative pain and inflammation were evaluated and compared between the two groups.
resultsAt 3, 7, and 14 d after the operation, the wound healing rate of the experimental group was significantly higher than that of the control group at any time point. The visual analogue scale scores of the two groups gradually decreased in a time-dependent manner after surgery, while the experimental group showed a more significant downward trend in comparison with the control group. At 14 d after the operation, the experimental group had high levels of epidermal growth factor, fibroblast growth factor-1, secretory IgA, tissue inhibitor of matrix metalloproteinase-1, 5-hydroxytryptamine, prostaglandin E-2, substances P and neuropeptide Y compared with control group, but low levels of C-reactive protein, procalcitonin, and serum amyloid A protein.
conclusionsThe Neibu Huangqi Youhua formula can reduce the levels of inflammatory factors and pain mediators in patients after anal fistula surgery, thereby accelerating the process of wound healing and alleviating the pain of patients.
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