Evidence map›Paper›PMID 40524291›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Pharmacological effect and possible mechanism of Mudan Huaban recipe on melasma in mice induced by ultraviolet B and progesterone.

Liu Xiaoyao, L I Jialin, Wang Weiling, Fan Qiongyin, S U Zeqi, H E Cheng, Wang Chunguo, Gao Jian, Wang Ting

Abstract read
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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Liu XiaoyaoSchool of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
L I JialinSchool of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
Wang WeilingBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
Fan QiongyinBeijing Institute of Pharmacology and Toxicology, Beijing Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China.
S U ZeqiBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
H E ChengBeijing Institute of Pharmacology and Toxicology, Beijing Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China.
Wang ChunguoBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
Gao JianKey Laboratory of Famous Doctors and Famous Prescriptions Under State Administration of Traditional Chinese Medicine, Beijing 102488, China.
Wang TingBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.

Funding

Beijing University of Chinese Medicine Transversal Project: "Internal and External" Product and Technology Development for Herbal Acne and Blemish Removal 2019110031001241Youth Project Under the National Natural Science Foundation of China: Revealing the Scientific Connotation of Tongfu Chinese Herb Rhubarb in Treating Ischemic Stroke from the Perspective of "Intestinal Tryptophan Metabolism and Central Microglia Polarisation" 82104440
6 · The paper itself

Abstract

objectiveTo analyze the chemical components of Mudan Huaban recipe (, MHR) and evaluate its efficacy and possible mechanism in melasma mice.

methodsThe chemical compositions of MHR were determined by the ultra-high performance liquid chromatography coupled with quadrupole-exactive mass spectrometry method. Female C57BL/6 mice were exposed to ultraviolet B and progesterone for 21 d to induce melasma, and Fontana-Masson staining was used to assess the effects of MHR on melasma. Luteinizing hormone (LH), estradiol, and follicle-stimulating hormone levels were detected by enzyme-linked immunosorbent assay. The superoxide dismutase (SOD) activity and malonic dialdehyde content were detected by chemiluminescence. Tyrosinase and related proteins expressions were detected by Western blots and immunohistochemistry.

resultsA total of 43 chemical components were identified in MHR, MHR significantly decreased the melanin particles of melasma mice. MHR treatment significantly reversed the high contents of LH and low activity of SOD in models. MHR significantly reduced the higher levels of tyrosinase, tyrosinase-related proteins-1 (TRP-1), TRP-2, microphthalmia-associated transcription factor and phosphorylation of cyclic adenosine monophosphate response element-binding protein (p-CREB)/CREB in the skin of melasma mice.

conclusionsMHR protects against melasma

Indexed as

Drugs, Chinese HerbalMelanosisProgesteroneAnimalsCyclic AMP Response Element-Binding ProteinFemaleFollicle Stimulating HormoneHumansLuteinizing HormoneMelaninsMiceMice, Inbred C57BLMonophenol MonooxygenaseOxidoreductasesSuperoxide DismutaseUltraviolet RaysCyclic AMP Response Element-Binding ProteinDrugs, Chinese HerbalFollicle Stimulating HormoneLuteinizing HormoneMelaninsMonophenol MonooxygenaseOxidoreductasesProgesteroneSuperoxide DismutasehormoneshyperpigmentationmelasmaMudan Huaban recipeoxidative stressskintyrosinase-related protein

Identifiers

PMID40524291
PMCPMC12134326

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