Evidence map›Paper›PMID 40524290›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Xiong's Shiwei Wendan decoction attenuates plaque lesions and balances gut microbiota dysbiosis in ApoE-/- mice with high-fat diet.

Liu Qian, Xiao Liuchen, Yuan Yue, Dang Xiaopeng, Wen Jie, Tan Moye, Liu Yuxin, G U Hongfeng, Xie Xuejiao

Abstract read
PubMed Full text at PMC Publisher
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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Liu QianGraduate School of Hunan University of Chinese Medicine, Changsha 410208, China.
Xiao LiuchenGraduate School of Hunan University of Chinese Medicine, Changsha 410208, China.
Yuan YueGraduate School of Hunan University of Chinese Medicine, Changsha 410208, China.
Dang XiaopengGraduate School of Hunan University of Chinese Medicine, Changsha 410208, China.
Wen JieGraduate School of Hunan University of Chinese Medicine, Changsha 410208, China.
Tan MoyeGraduate School of Hunan University of Chinese Medicine, Changsha 410208, China.
Liu YuxinGraduate School of Hunan University of Chinese Medicine, Changsha 410208, China.
G U HongfengHengyang Key Laboratory of Neurodegeneration and Cognitive Impairment and Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang 421001, China.
Xie XuejiaoDepartment of Zhong jing' Theory, College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China.

Funding

Health Research Project of Hunan Provincial Health Commission: the An-ti-Atherosclerotic Mechanism of Xiong's Shiwei Wendan Decoction based on Lipophagy Mediated by the MicroRNA-499a-3p/ Autophagy-related 5 Pathway D202303018265National Natural Science Foundation of China: the Anti-Atherosclerotic Mechanism of Xiong's Shiwei Wendan decoction based on the Regulation of Reverse Cholesterol Transport via the MicroRNA-33A Adenosine Triphosphate-binding Cassette Subfamily A Member 1/ Adenosine Triphosphate-binding Cassette Subfamily A Member 1 Pathway 81603600Natural Science Foundation of Hunan Province of China: the Anti-Atherosclerotic Mechanism of Xiong's Shiwei Wendan Decoction based on the Activation of Lipophagy Mediated by the AMP-activated Protein Kinase/Mechanistic Target of Rapamycin Pathway 2021JJ30510
6 · The paper itself

Abstract

objectiveTo evaluate the anti-atherosclerotic potential and gut microbiota (GM) modulation effects of Xiong's Shiwei Wendan decoction (, XSWD).

methodsFor

resultsXSWD administration attenuated lipid deposition in THP-1 cells, significantly reduced aortic plaque lesions, improved the lipid profile, and normalized GM composition in HFD-fed ApoE-/- mice.

conclusionThis study investigated the potential anti-atherosclerotic and gut microbio-ta-restoring effects of XSWD in ApoE-/- mice, with findings suggesting that XSWD may be a promising preventive measure against atherosclerosis through its ability to reduce lipid accumula-tion in foam cells, improve lipid profile, and restore gut microbiota composition.

Indexed as

Apolipoproteins EAtherosclerosisDrugs, Chinese HerbalDysbiosisGastrointestinal MicrobiomePlaque, AtheroscleroticAnimalsDiet, High-FatHumansMaleMiceMice, Inbred C57BLMice, KnockoutApolipoproteins EDrugs, Chinese Herbalatherosclerosisgastrointestinal microbiomelipid metabolismXiong's Shiwei Wendan decoction

Identifiers

PMID40524290
PMCPMC12134321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.