Evidence map›Paper›PMID 40524195›Full record

ArticleFluids and barriers of the CNS2025

Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study.

Ella Rowsthorn, Lachlan Cribb, Benjamin Sinclair, William Pham, Trevor T-J Chong, Stephanie Yiallourou, Marina Cavuoto, Lucy Vivash, Terence J O'Brien, Xingfeng Shao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fluids and barriers of the CNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ella RowsthornDepartment of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
Lachlan CribbSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.
Benjamin SinclairDepartment of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
William PhamDepartment of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
Trevor T-J ChongSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.
Stephanie YiallourouSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.
Marina CavuotoSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.
Lucy VivashDepartment of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
Terence J O'BrienDepartment of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
Xingfeng ShaoLaboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Danny J J WangLaboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Meng LawDepartment of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
Matthew P Pase *School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia. matthew.pase@monash.edu.
Ian H Harding *Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia. ian.harding@qimrberghofer.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluid transport in the neurovascular unit is essential for maintaining brain health through nutrient delivery and waste clearance. However, these systems are complex and the inter-dependencies between elements of these systems and how they may change through aging is not well understood. MRI outcomes provide insight into the underlying biological mechanisms of these systems in vivo, including water exchange rate through the neurovascular unit (BBB k

Indexed as

AgingBlood-Brain BarrierBrainCerebrovascular CirculationGlymphatic SystemNeuroimagingAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingWhite MatterAgingFluid transportGlymphatic clearanceMulti-modal MRINeurovascular unitVascular health

Identifiers

PMID40524195
PMCPMC12168365

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.