Evidence map›Paper›PMID 40524017›Full record

ArticleNature immunology2025

The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation.

Zhou Yu, Xuelian Li, Jiaying Huang, Jueyu Pan, Jiale Cheng, Ping Liu, Mingjin Yang, Taoyong Chen, Qian Zhang, Yumei Zhou and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Polysaccharide-Based Encapsulation of Microbes for Enhanced Microbial Therapy.Polymer science & technology (Washington, D.C.) · 2026
    Review
  3. Review
  4. Caerin 1.1/1.9 peptides controlFrontiers in microbiology · 2026
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zhou Yu *National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China. yz@ism.cams.cn.ORCID http://orcid.org/0000-0002-9910-3274
Xuelian Li *National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.ORCID http://orcid.org/0000-0003-3114-7729
Jiaying HuangInstitute of Immunology, Naval Medical University, Shanghai, China.
Jueyu PanNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.ORCID http://orcid.org/0009-0003-2364-0086
Jiale ChengNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.
Ping LiuNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.
Mingjin YangInstitute of Immunology, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0003-2350-1054
Taoyong ChenInstitute of Immunology, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0002-2507-0027
Qian ZhangInstitute of Immunology, Naval Medical University, Shanghai, China.
Yumei ZhouNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.ORCID http://orcid.org/0009-0007-0409-1121
Jiacheng WuDepartment of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-9022-8169
Taotao HanDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Jingnan LiDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Yue XuDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.ORCID http://orcid.org/0009-0001-9215-436X
Mingyue WenNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.ORCID http://orcid.org/0000-0001-9372-2579
Xuan ZhangDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-8775-1699
Chunmei WangNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.
Xuetao CaoNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China. caoxt@immunol.org.ORCID http://orcid.org/0000-0001-9677-7647

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32300725National Natural Science Foundation of China (National Science Foundation of China) 32370929
6 · The paper itself

Abstract

E3 ligases and RNA-binding protein-mediated dysregulation of proinflammatory cytokines leads to autoimmune and inflammatory diseases. However, whether RNA-binding E3 ligases can regulate specific proinflammatory cytokine expression remains unclear. Here we found that the RNA-binding E3 ligase MKRN2 selectively inhibits the expression of interleukin-6 (IL-6) in lipopolysaccharide-activated macrophages. LysM-Cre

Indexed as

InflammationInterleukin-6Ubiquitin-Protein LigasesAnimalsArthritis, RheumatoidColitisColitis, UlcerativeDisease Models, AnimalHumansLipopolysaccharidesMacrophagesMiceMice, Inbred C57BLMice, KnockoutProtein BiosynthesisInterleukin-6LipopolysaccharidesUbiquitin-Protein Ligases

Identifiers

PMID40524017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.