Evidence map›Paper›PMID 40523976›Full record

ArticleSurgical endoscopy2025

Devices for minimally invasive liver parenchyma transection: the SICE (Italian Society of Endoscopic Surgery) Italian and International survey.

Graziano Ceccarelli, Pasquale Avella, Edoardo Maria Muttillo, Maria Conticchio, Giovanni Domenico Tebala, Gaetano Piccolo, Lucia Romano, Riccardo Memeo, Aldo Rocca, LIVER-MIND (Minimally Invasive Surgery and pareNchyma transection Devices) Study Group

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07750275 (Safety and Economics of Parenchymal Transection in Minimally Invasive Liver Surgery), which is not on this map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07750275 enrolling by invitationnot on this map

Safety and Economics of Parenchymal Transection in Minimally Invasive Liver Surgery (LIVER-MIND 2): a Multicentre Retrospective Registry of the Italian Society of Endoscopic Surgery (SICE)

TypeobservationalSponsorUniversity of MoliseRan2021 to 2027Enrolled800ConditionsLiver Surgery, MINIMALLY INVASIVE LIVER SURGERY, Liver Neoplasm
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Graziano CeccarelliDepartment of General Surgery, San Giovanni Battista" Hospital, USL Umbria 2, Foligno, Perugia, Italy.
Pasquale AvellaDepartment of Medicine and Health Science "V. Tiberio", University of Molise, Campobasso, Italy. avella.p@libero.it.ORCID http://orcid.org/0000-0003-4910-5404
Edoardo Maria MuttilloDepartment of Medical Surgical Science and Translational Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
Maria ConticchioUnit of Hepato-Pancreato-Biliary Surgery, Miulli Hospital, Acquaviva delle Fonti, Bari, Italy.
Giovanni Domenico TebalaDepartment of Digestive and Emergency Surgery, S. Maria Hospital Trust, Terni, Italy.
Gaetano PiccoloDepartment of Health Sciences (DISS), General Surgery Unit, University of Milan San Paolo Hospital, Milan, Italy.
Lucia RomanoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Riccardo MemeoUnit of Hepato-Pancreato-Biliary Surgery, Miulli Hospital, Acquaviva delle Fonti, Bari, Italy.
Aldo RoccaDepartment of Medicine and Health Science "V. Tiberio", University of Molise, Campobasso, Italy.
LIVER-MIND (Minimally Invasive Surgery and pareNchyma transection Devices) Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsMinimally Invasive Liver Surgery (MILS), encompassing laparoscopic (L-MILS) and robotic (R-MILS) approaches, has revolutionized liver surgery, offering reduced morbidity, shorter hospital stays, and improved outcomes while maintaining oncological efficacy. Despite the widespread use of L-MILS, parenchyma liver transection techniques and devices remain debated. This study investigates the adoption of transection devices (TDs) in MILS among 86 hospitals, focusing on surgical practices, device utilization, and outcomes.

methodsThe Italian Society of Endoscopic Surgery (SICE) endorsed a cross-sectional internet-based survey targeting general and Hepato-Pancreato-Biliary surgeons.

resultsResponses from 86 centers revealed that 77% of institutions is available a robotic platform, with an adoption rate of 87.50% in high-volume centers. L-MILS remains the predominant technique for liver resections, also in case of major hepatectomies, although R-MILS is increasingly utilized. For minor L-MILS, more than 50% of respondents use ultrasonic shears and electrosurgical pencil and advanced bipolar devices, while about 40% of surgeons adopt Cavitronic Ultrasonic Surgical Aspirator (CUSA) in major resections. R-MILS procedures predominantly used Maryland bipolar forceps and vessel sealers, with hybrid techniques (30%) integrating laparoscopic devices (e.g., CUSA) to address robotic device limitations.

conclusionThe minimally invasive approach to liver parenchymal transection is a key component of this surgical procedure. For major hepatectomies, the CUSA device remains the most effective tool, whereas ultrasonic shears, electrosurgical pencil, and advanced bipolar devices are more suited for minor resections. Despite limited access to specialized instruments, R-MILS achieves favorable outcomes in liver transection by employing the crash-clamp technique or hybrid strategies.

Indexed as

HepatectomyLaparoscopyPractice Patterns, Physicians'Robotic Surgical ProceduresCross-Sectional StudiesHumansItalySurveys and QuestionnairesHigh energy deviceHigh volumeIndocyanine green fluorescenceLaparoscopic liver surgeryLiver parenchymaLiver surgeryLow volumeMedium volumeMinimally invasive surgeryRobotic liver surgery

Identifiers

PMID40523976
PMCPMC12287225

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.