ArticleOncogene2025
NNMT-mediated N
Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- NNMT and the methylation sink: integrating metabolism, epigenetics and immunity in cancer.BMC medicine · 2026Review
- PSMD14-mediated PFKFB2 deubiquitination activates H3K27 lactylation to drive cancer stemness in gastric adenocarcinoma.Cell death and differentiation · 2026Article
- RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability.Oncogene · 2026Article
- Prognostic potential of N6-methyladenosine methylation-associated genes in lung adenocarcinoma.Translational cancer research · 2025Article
- Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.Journal of experimental & clinical cancer research : CR · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Lymph node (LN) metastasis is a common feature of gastric adenocarcinoma (GAC) and is closely associated with a poor prognosis. Our previous study highlighted the pivotal role of nicotinamide N-methyltransferase (NNMT) in driving GAC carcinogenesis and malignant progression, primarily through its regulation of histone methylation. However, the mechanisms by which NNMT contributes to LN metastasis in GAC remain poorly understood. In this study, we demonstrated that elevated NNMT expression was positively correlated with LN metastasis and a poor prognosis in GAC patients. Gain- and loss-of-function experiments further revealed that NNMT accelerated GAC-related lymphangiogenesis, migration, and invasion in vitro and facilitated LN metastasis in vivo. Mechanistically, NNMT promoted the degradation of NR4A3 mRNA by diminishing its m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.