Evidence map›Paper›PMID 40523942›Full record

ReviewNature reviews. Neuroscience2025

Cerebellar circuit computations for predictive motor control.

Katrina P Nguyen, Abigail L Person

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cerebellar contributions to action and cognition: Prediction, timescale, and continuity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026
    Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katrina P NguyenDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-5946-5983
Abigail L PersonDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. abigail.person@cuanschutz.edu.ORCID http://orcid.org/0000-0001-9805-7600

Funding

Circuit mechanisms of cerebellar control of reaching movementsR01NS114430 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Jason M Christie, Abigail L Person · 2019 to 2026
$3.4M
Functional roles of inhibitory cerebellar outputsR37NS131839 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Abigail L Person · 2024 to 2026
$1.5M
Spatiotemporal encoding of goal-directed reaching across early cerebellar circuitryF32NS134561 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Katrina Nguyen · 2024 to 2026
$229k
NINDS NIH HHS F32 NS134561NINDS NIH HHS R01 NS114430NINDS NIH HHS R37 NS131839
6 · The paper itself

Abstract

The rise of the deep neural network as the workhorse of artificial intelligence has brought increased attention to how network architectures serve specialized functions. The cerebellum, with its largely shallow, feedforward architecture, provides a curious example of such a specialized network. Within the cerebellum, tiny supernumerary granule cells project to a monolayer of giant Purkinje neurons that reweight synaptic inputs under the instructive influence of a unitary synaptic input from climbing fibres. What might this predominantly feedforward organization confer computationally? Here we review evidence for and against the hypothesis that the cerebellum learns basic associative feedforward control policies to speed up motor control and learning. We contrast and link this feedforward control framework with another prominent set of theories proposing that the cerebellum computes internal models. Ultimately, we suggest that the cerebellum may implement control through mechanisms that resemble internal models but involve model-free implicit mappings of high-dimensional sensorimotor contexts to motor output.

Indexed as

CerebellumModels, NeurologicalMotor ActivityNerve NetAnimalsHumansLearningNeural Networks, ComputerNeural Pathways

Identifiers

PMID40523942
PMCPMC12643008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.