ArticleNature chemistry2025
On-DNA C-H functionalization of electron-rich arenes for DNA-encoded libraries.
Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- DNA-scaffolded catalysis for aliphatic alcohol oxidation in DEL synthesis.Chemical science · 2026Article
- On-DNA photochemical methods for expanding DNA-encoded library (DEL) chemical space.RSC medicinal chemistry · 2026Review
- Thianthrenium Salts in Photochemistry.Accounts of chemical research · 2026Article
- Cationic Selenuranes - Bench-Stable Sources of Se(III) Radicals.Angewandte Chemie (International ed. in English) · 2025Article
- Selenoxides unlock C-H bonds of biomacromolecules.Nature chemistry · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA-encoded libraries (DELs) are useful for hit discovery in the pharmaceutical industry. Although a large number of individually coded molecules are accessible through DELs, their structural diversity is limited because few transformations are benign and chemoselective enough to be applied in the presence of DNA in aqueous environments. In particular, C-H functionalization chemistry that could be ideally suited to increase structural diversity through late-stage functionalization is currently absent from DEL synthesis. Here we present a general C-H functionalization of electron-rich arenes on DNA. The development of a selenoxide reagent is key to achieving the regio- and chemoselective formation of arylselenonium salts in aqueous media. The introduction of arylselenonium salts offers a versatile linchpin on DNA conjugates, which gives access to a multitude of analogues through diverse subsequent reactions, including transition-metal-mediated and photochemical transformations for the formation of C-C, C-I and C-S bonds.
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