Evidence map›Paper›PMID 40523903›Full record

ArticleNPJ precision oncology2025

ECT2

Wanling Chen, Yang Wang, Zhengduo Yao, Ting Gu, Yuhua Hu, Nannan Leng, Chunye Zhang, Zhen Tian, Jiang Li

Abstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wanling Chen *Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang Wang *Department of Stomatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhengduo YaoDepartment of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ting GuDepartment of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuhua HuDepartment of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nannan LengDepartment of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chunye ZhangDepartment of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yezi1806@126.com.
Zhen TianDepartment of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Tian_030412@126.com.
Jiang LiDepartment of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lijiang182000@126.com.

Funding

National Natural Science Foundation of China 82273017Natural Science Foundation of Shanghai 22ZR1437000the Clinical Research Plan of the Shanghai Ninth People's Hospital JYLJ202119the National Key Research and Development Program of China 2022YFC2504200the Shanghai's Top Priority Research Center 2022ZZ01017
6 · The paper itself

Abstract

Salivary carcinoma ex pleomorphic adenoma (CXPA) is a carcinoma that develops from benign pleomorphic adenoma, and it is characterized by aggressiveness and poor prognosis. Recent advancements in cancer stem cell (CSC) research have identified CSCs as critical contributors to tumor carcinogenesis due to their unlimited self-renewal ability. Single-cell RNA sequencing has enabled a comprehensive analysis of CSC heterogeneity. However, CSCs in CXPA remain largely unexplored. In this study, we constructed a comprehensive atlas of CXPA at single-cell resolution and demonstrated that CXPA exhibited intratumoral heterogeneity. We identified four tumor epithelial cell subgroups characterized by epithelial development, cell cycle, extracellular matrix remodeling, and salivary secretion signatures. ECT2

Identifiers

PMID40523903
PMCPMC12170905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.