Evidence map›Paper›PMID 40523777›Full record

ArticleeNeuro2025

Deletion of Endocannabinoid Synthesizing Enzyme DAGLα in Pcp2-Positive Cerebellar Purkinje Cells Decreases Depolarization-Induced Short-Term Synaptic Plasticity, Reduces Social Preference, and Heightens Anxiety.

Gabriella Smith, Kathleen McCoy, Gonzalo Viana Di Prisco, Alexander Kuklish, Emma Grant, Mayil Bhat, Sachin Patel, Ken Mackie, Brady Atwood, Anna Kalinovsky

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Gabriella SmithGill Institute for Neuroscience, Indiana University, Bloomington, Indiana 47405.
Kathleen McCoyGill Institute for Neuroscience, Indiana University, Bloomington, Indiana 47405.
Gonzalo Viana Di PriscoDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 47405.
Alexander KuklishGill Institute for Neuroscience, Indiana University, Bloomington, Indiana 47405.
Emma GrantGill Institute for Neuroscience, Indiana University, Bloomington, Indiana 47405.
Mayil BhatGill Institute for Neuroscience, Indiana University, Bloomington, Indiana 47405.
Sachin PatelDepartment of Molecular Physiology and Biophysics, Department of Psychiatry, Vanderbilt Brain Institute, Vanderbilt-Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Ken MackieGill Institute for Neuroscience, Indiana University, Bloomington, Indiana 47405.
Brady AtwoodDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 47405.
Anna KalinovskyGill Institute for Neuroscience, Indiana University, Bloomington, Indiana 47405 akalinov@iu.edu.

Funding

Multi-Scale Imaging Core (MSIC)P30DA056410 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI Kenneth Mackie · 2023 to 2026
$7.1M
2-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptationR01MH107435 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, SACHIN · 2016 to 2025
$5.0M
Cannabinoids play a central role in cerebellar developmentR21DA044000 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI KALINOVSKY, ANNA, MACKIE, KENNETH · 2018 to 2019
$433k
NIDA NIH HHS P30 DA056410NIDA NIH HHS R21 DA044000NIMH NIH HHS R01 MH107435
6 · The paper itself

Abstract

The endocannabinoid (eCB) signaling system is robustly expressed in the cerebellum from embryonic developmental stages to adulthood. It plays a key role in regulating cerebellar synaptic plasticity and excitability, suggesting that impaired eCB signaling could lead to deficits in cerebellar adjustments of ongoing behaviors and cerebellar learning. Indeed, human mutations in

Indexed as

AnxietyLipoprotein LipaseNeuronal PlasticityPurkinje CellsSocial BehaviorAnimalsCerebellumEndocannabinoidsMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicEndocannabinoidsLipoprotein LipasecannabinoidcerebellumDAGLαDSEDSIPurkinje

Identifiers

PMID40523777
PMCPMC12308783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.