ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
EZH2 promotes malignant biological behavior in esophageal squamous cell carcinoma via EMT.
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- EZH2 and MMP1 Overexpression in Colorectal Cancer: Correlation with Tumor Aggressiveness and Clinicopathologic Features.Iranian journal of pathology · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
objectivesEsophageal squamous cell carcinoma (ESCC) is characterized by complex pathogenesis and poor prognosis. In recent years, epithelial-mesenchymal transition (EMT) in tumor initiation and progression has attracted increasing attention. Enhancer of zeste homolog 2 (EZH2), which is aberrantly expressed in various tumors, may be closely related to the EMT process. This study aims to examine the expression and correlation of EZH2 and EMT markers in ESCC cells and tissues, evaluate the effects of
methodsBioinformatics analyses were used to assess EZH2 expression levels in ESCC. Small interfering RNA was used to knock down
resultsBioinformatics analysis showed that
conclusionsEZH2 promotes malignant biological behavior in ESCC by mediating EMT. Elevated EZH2 expression is associated with poor prognosis in ESCC patients.
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