Evidence map›Paper›PMID 40523671›Full record

ArticleImmunology2025

CD59, Disulphide-Locked Human C9 and Horse C9 Inhibit Human Membrane Attack Complex Assembly by Similar Mechanisms.

Rebekah S Cooke, Bradley A Spicer, Richard A Harrison, Michelle A Dunstone, B Paul Morgan, Wioleta M Zelek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rebekah S CookeDivision of Infection and Immunity and UK Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.
Bradley A SpicerARC Centre of Excellence in Advanced Molecular Imaging and Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.
Richard A HarrisonDivision of Infection and Immunity and UK Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.
Michelle A DunstoneARC Centre of Excellence in Advanced Molecular Imaging and Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.
B Paul MorganDivision of Infection and Immunity and UK Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0003-4075-7676
Wioleta M ZelekDivision of Infection and Immunity and UK Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-2230-3550

Funding

Alzheimer's Society 565Race Against Dementia Alzheimer's Research UK 520488UK Dementia Research Institute UK DRI-3002
6 · The paper itself

Abstract

Five plasma proteins, C5b, C6, C7, C8 and C9, assemble in a step-wise manner to form the membrane attack complex (MAC) which inserts into target cell membranes to cause lysis. The membrane regulator CD59 binds nascent C5b-8, preventing C9 recruitment and polymerisation into the lytic pore. A disulphide-locked C9 ('C9lock'; C9

Indexed as

CD59 AntigensComplement C9Complement Membrane Attack ComplexDisulfidesAnimalsHemolysisHorsesHumansProtein BindingCD59 AntigensCD59 protein, humanComplement C9Complement Membrane Attack ComplexDisulfidesC9CD59complementdrugsmembrane attack complex

Identifiers

PMID40523671
PMCPMC12500384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.