Evidence map›Paper›PMID 40523246›Full record

ArticleJournal of the American Chemical Society2025

Nitrite Causes Nitrosative Stress to Iron Sulfur Clusters.

Subhadeep Bera, Arijeet Ghude, Vincent J Catalano, Jean-Marie Mouesca, Ricardo García-Serres, Leslie J Murray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Subhadeep BeraCenter for Catalysis and Florida Center for Heterocyclic Chemistry, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Arijeet GhudeCenter for Catalysis and Florida Center for Heterocyclic Chemistry, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Vincent J CatalanoDepartment of Chemistry, University of Nevada, Reno, Nevada 89557, United States.ORCID 0000-0003-2151-2892
Jean-Marie MouescaUniversité Grenoble Alpes, CNRS, CEA/IRIG-SyMMES, 17 Rue des Martyrs, F-38054 Grenoble, France.ORCID 0000-0001-7497-1430
Ricardo García-SerresUniversité Grenoble Alpes, CNRS, CEA, BIG, LCBM (UMR 5249), F-38054 Grenoble, France.ORCID 0000-0001-5203-0568
Leslie J MurrayCenter for Catalysis and Florida Center for Heterocyclic Chemistry, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0002-1568-958X

Funding

Ligand effects on reactivity of hydride-decorated and reduced multi-iron compoundsR01GM123241 · NIGMS · UNIVERSITY OF FLORIDA · PI MURRAY, LESLIE JUSTIN · 2017 to 2021
$1.4M
Acquisition of timsTOF Pro for Complex Lipidomic AnalysesS10OD030250 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2022 to 2022
$658k
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
NIGMS NIH HHS R01 GM123241NIH HHS S10 OD021758NIH HHS S10 OD030250
6 · The paper itself

Abstract

Nitric oxide (NO), produced by nitrite reductases or nitric oxide synthases, performs vital roles in signaling and the immune response. Iron sulfur (FeS) clusters are known targets for NO induced degradation, serving as sensors to trigger cellular responses. However, this FeS reactivity is proposed as NO specific, with no demonstrated reactivity toward nitrite, a soluble NO storage molecule. We demonstrate that synthetic FeS clusters supported by various ligands undergo facile nitrosylation by nitrite in the presence of a reductant, evidencing the nitrite reductase reactivity for FeS clusters. Moreover, a mononitrosylated Fe

Indexed as

IronIron-Sulfur ProteinsNitric OxideNitritesNitrosative StressSulfurIronIron-Sulfur ProteinsNitric OxideNitritesSulfur

Identifiers

PMID40523246
PMCPMC12449781

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.