ArticleThe journal of extra-corporeal technology2025
Is hyperoxia in early pediatric veno-veno extracorporeal life support associated with mortality?
Article in The journal of extra-corporeal technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundData is limited regarding the effects of supraphysiologic blood oxygen tension (hyperoxia) in patients requiring extracorporeal life support (ECLS). We sought to evaluate the association between hyperoxia and outcomes in pediatric patients requiring veno-venous (VV) ECLS.
methodsRetrospective single-center study at an academic children's hospital, Children's Healthcare of Atlanta, Emory University School of Medicine that included all patients 0-18 years who required VV-ECLS between 01/2014 and 12/2019.
resultsDuring the study period 110 VV-ECLS runs occurred in 110 patients. Using a receiver operating characteristic curve, a mean partial pressures of oxygen (PaO
conclusionChildren exposed to hyperoxia during the first 48 h of VV-ECLS were 8 times more likely to die than those who were not after adjusting for confounders (age group, body surface area, and indication for ECLS). Multicenter and prospective evaluation of this modifiable risk factor is imperative to improving the care of this high-risk cohort.
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