Evidence map›Paper›PMID 40523107›Full record

ReviewAnnual review of virology2025

Spatial Transcriptomics to Study Virus-Host Interactions.

Chase Holdener, Shaowen Jiang, Danica M Sutherland, Kira A Griswold, Terence S Dermody, John S L Parker, Iwijn De Vlaminck

Abstract readReview
In one paragraph

Review in Annual review of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chase HoldenerMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA; email: vlaminck@cornell.edu.
Shaowen JiangMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA; email: vlaminck@cornell.edu.
Danica M SutherlandDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kira A GriswoldInstitute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Terence S DermodyDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
John S L ParkerBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; email: jsp7@cornell.edu.
Iwijn De VlaminckMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA; email: vlaminck@cornell.edu.

Funding

Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
A spatially resolved molecular atlas of acute viral myocarditis at single-cell resolutionR01AI176681 · NIAID · CORNELL UNIVERSITY · PI Iwijn De Vlaminck, John S Parker · 2023 to 2026
$3.1M
Reovirus NeuropathogenesisR01AI174526 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TERENCE S. DERMODY · 2022 to 2026
$2.7M
NIAID NIH HHS R01 AI174526NIAID NIH HHS R01 AI176681NIAID NIH HHS T32 AI049820
6 · The paper itself

Abstract

The morbidity and mortality associated with viral diseases in plants, animals, and humans are significant concerns. Understanding how viruses cause disease and identifying the viral and host factors that determine the outcome of infection are essential to develop new antiviral therapeutics and strategies to induce protective immunity. In this review, we focus on the transformative potential of spatial transcriptomics for studies of viral pathogenesis and some of the intricacies of corresponding technologies and how to implement them.

Indexed as

Gene Expression ProfilingHost-Pathogen InteractionsTranscriptomeVirus DiseasesVirusesAnimalsHumansPlantsRNA sequencingspatial transcriptomicsviral immunologyviral pathogenesisviral tropism

Identifiers

PMID40523107
PMCPMC12683572

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.