ArticleMagnetic resonance in medicine2025
3D-printable phantoms for quantitative dynamic contrast-enhanced MRI.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- 3D-printable phantoms for quantitative dynamic contrast-enhanced MRI.Magnetic resonance in medicine · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
purposeA novel 3D-printed phantom design and methodology are proposed, addressing important requirements for technical validation, quality assurance, and multi-site harmonization of quantitative DCE-MRI measurements.
methodsPhantoms were produced by 3D-printing (3DP) gels incorporating channels and pores as proxies for blood vessels and extravascular extracellular space, respectively. A flow circuit was designed to reproduce clinically relevant arterial input functions. Using nine gels with variable porosity and channel size, we evaluated the effect of 3DP parameters on DCE-MRI parameters obtained using the extended Tofts model (ET). Physical gel and fitted model parameters were correlated by multiple linear regression.
resultsAll phantoms generated realistic arterial input functions, and tissue-like signal enhancement curves were accurately modeled by the ET model. As hypothesized, blood plasma volume fraction, v
conclusionsTailorable 3D-printed porous gel phantoms generating tissue-mimicking DCE-MRI signals have the potential to support validation, quality assurance, and multi-site harmonization of quantitative DCE-MRI.
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