ArticleSchizophrenia bulletin2026
Association between the Korea-Polyenvironmental Risk Score and Clinical Outcomes in Schizophrenia Spectrum Disorders.
Article in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Environmental risk score as a predictor for 25-year symptom and functional trajectories in first episode psychosis.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundEvidence suggests that environmental factors increase the risk of psychosis development and influence the prognosis of psychotic disorders. This study examined the discriminative validity of the Korea-Polyenvironmental Risk Score (K-PERS) in differentiating patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs). In addition, we evaluated its associations with baseline clinical characteristics and short-term clinical outcomes. STUDY
designData were obtained from participants of the Korea Early Psychosis Study, who were assessed using K-PERS and underwent clinical evaluations at baseline and at 2, 6, and 12 months. Matched HCs were recruited for comparison. Psychopathology, cognitive functioning, and socio-occupational functioning were assessed using the Positive and Negative Syndrome Scale (PANSS), Prospective and Retrospective Memory Questionnaire (PRMQ), and Social and Occupational Functioning Assessment Scale (SOFAS). Treatment response, remission, and recovery were evaluated based on predefined criteria.
resultsA total of 224 subjects with SSD and 203 HC were enrolled in this study. K-PERS-I and K-PERS-II demonstrated good predictive performance, with area under the curve values of 0.738 and 0.754, respectively. At baseline, K-PERS-I and K-PERS-II were significantly associated with depressive and negative symptoms, PRMQ scores, SOFAS scores, and various self-reported measures. Importantly, several individual item scores or total score of K-PERS predicted treatment response, remission, or recovery.
conclusionsK-PERS has a good discriminative ability for identifying SSDs within the general population. Furthermore, K-PERS is associated with symptom severity, cognitive performance, and socio-occupational functioning, and it significantly influences the illness course.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.