ArticleThe Journal of clinical endocrinology and metabolism2026
Maternal Thyroid Function During Pregnancy and Early Adolescent Regional Differences in Cerebral Gray Matter Morphology.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Relationship between parity and subclinical hypothyroidism in a large cohort of pregnant women without thyroid diseases.Journal of the Endocrine Society · 2026Article
- Maternal Thyroid Function During Pregnancy and Early Adolescent Regional Differences in Cerebral Gray Matter Morphology.The Journal of clinical endocrinology and metabolism · 2026Article
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5 authors.
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Abstract
backgroundThyroid hormone regulates fetal brain development. Both low and high maternal thyroid function during early pregnancy has been associated with smaller offspring total gray matter and cortex volume. However, it remains unknown whether regional gray matter differences underlie global brain morphology findings.
aimTo assess the association of gestational thyroid function with regional gray matter morphology through detailed vertex-wise analysis of cortical surface area and thickness and volumetric analyses of subcortical gray matter.
methodsWe enrolled 2426 women of the population-based prospective cohort Generation R with TSH and/or free T4 (FT4) assessment before 18 weeks of gestation and offspring brain magnetic resonance imaging scans at age 10 and/or 14 years. We studied the association of gestational TSH, FT4, and (sub)clinical thyroid disease entities with local cortical surface area, thickness, and subcortical volumes.
resultsThere was an inverse J-shaped association of TSH with cortical surface area in the rostral middle frontal region (β [SE] for quadratic TSH: -0.005 [0.001] mm2, linear TSH 0.009 [0.004]). FT4 was not associated with cortical measures. Post hoc analyses revealed an inverse J-shaped association of TSH with gyrification in a similar region and children of hyperthyroid women had less gyrification in 3 cortical regions, mainly frontal (-0.082 [0.022], -0.077 [0.020], -0.069 [0.020]). Moreover, there was an inverse U-shaped association of FT4 with caudate volume (β [SE] for quadratic FT4: -0.004 [0.001] SD, linear FT4 0.010 [0.010]). TSH and FT4 were not associated with other subcortical volumes.
conclusionMaternal thyroid function during early pregnancy is associated with offspring cerebral gray matter morphology in certain brain regions, specifically the frontal lobe. These findings expand on global brain morphology associations and support previous associations with behavioral outcomes.
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