Evidence map›Paper›PMID 40522719›Full record

ArticleJournal of periodontology2026

Effect of smoking over one pack daily on implant healing and health: A cohort study.

Yaniv Mayer, Eran Gabay, Eli E Machtei, Eli Regev, Ofir Ginesin, Zvi Gutmacher, Jacob Horwitz, Luigi Canullo, Jamil Awad Shibli, Hadar Giladi Zigdon

Abstract read
In one paragraph

Article in Journal of periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yaniv MayerDepartment of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus (RHCC), Haifa, Israel.ORCID https://orcid.org/0000-0001-5500-7961
Eran GabayDepartment of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus (RHCC), Haifa, Israel.ORCID https://orcid.org/0000-0003-0429-2883
Eli E MachteiDepartment of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus (RHCC), Haifa, Israel.ORCID https://orcid.org/0000-0001-6636-0138
Eli RegevDepartment of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus (RHCC), Haifa, Israel.
Ofir GinesinDepartment of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus (RHCC), Haifa, Israel.ORCID https://orcid.org/0000-0002-8736-9753
Zvi GutmacherFaculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Jacob HorwitzUnit of Periodontology, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel.
Luigi CanulloDepartment of Surgical Sciences (DISC), Division of Prosthodontics and Implant Prosthodontics, University of Genoa, Genova, Italy.ORCID https://orcid.org/0000-0001-9875-2929
Jamil Awad ShibliDepartment of Periodontology, Dental Research Division, Guarulhos University, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1971-0195
Hadar Giladi ZigdonDepartment of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus (RHCC), Haifa, Israel.ORCID https://orcid.org/0000-0002-4940-6533

Funding

Alpha-Bio Tec. Ltd.
6 · The paper itself

Abstract

backgroundThis prospective cohort trial examines the effects of heavy smoking on peri-implant marginal bone loss (MBL) and implant survival rates over 15 months.

methodsThirty subjects, categorized as either smokers (more than 20 cigarettes daily for over 5 years) or non-smokers, were initially recruited with pocket depths ≤ 5 mm and at least one missing tooth. Urine cotinine assay was used to confirm smoking status. Implants were placed and restored after 4 months. Clinical, radiographic and stability variables were assessed at placement, 15, 24, and 67 weeks. Measurements included marginal bone height, peri-implant pocket depth, implant stability, bleeding on probing, and plaque index. Statistical analyses included Mann-Whitney tests for continuous variables, Fisher exact tests for categorical variables, and generalized estimating equations for longitudinal changes.

resultsThirteen implants were installed in the smoker group (11 subjects) and 18 in the non-smoker group (18 subjects). Survival rates were lower in smokers (84.6%) compared with non-smokers (94.4%). Smokers experienced significantly greater marginal bone loss 12 months after final reconstruction (1.5 ± 0.3 mm versus 0.7 ± 0.6 mm; p = 0.008). Pocket depth was slightly greater in smokers but this did not reach statistical significance.

conclusionsHeavy smoking significantly increases marginal bone loss and decreases implant survival. Further research is needed to corroborate these findings and develop intervention programs. PLAIN LANGUAGE SUMMARY: Heavy smoking is a well-known risk factor for poor dental health, yet its effects on dental implants are less frequently examined. This study investigated how heavy smoking (more than 20 cigarettes daily for at least 5 years) impacts the success of dental implants. We monitored 29 patients, including both heavy smokers and non-smokers, over 15 months after implant placement and restoration. We evaluated bone loss, implant stability, and success rates. Our results showed that heavy smokers experienced significantly more bone loss-twice as much as non-smokers-along with slightly reduced implant stability and survival. These adverse outcomes likely relate to smoking's negative effects on bone healing and immune function. Our findings underscore the importance of addressing smoking before implant procedures and suggest that quitting smoking could greatly improve long-term outcomes. Further research is needed to develop strategies for mitigating the risks of smoking in implant dentistry.

Indexed as

Alveolar Bone LossDental ImplantsSmokingAdultAgedCohort StudiesCotinineDental Implantation, EndosseousDental Plaque IndexDental Restoration FailureFemaleHumansMaleMiddle AgedPeriodontal IndexProspective StudiesCotinineDental Implantsbone lossbone remodelingdental implantsimplant survival ratemarginal bone lossperi‐implantitissmoking

Identifiers

PMID40522719
PMCPMC12902707

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.