ArticleACS applied materials & interfaces2025
The Role of Acoustic Parameters in Droplet Vaporization of Perfluoropentane Nanodroplets for
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Investigation of a GPC1-targeted and LIFU-responsive nanoplatform with ADV effect for visualized chemo-sonodynamic therapy against pancreatic ductal adenocarcinoma.Journal of cancer research and clinical oncology · 2026Article
- Quantum-edge synergy for dynamic acoustic compensation in ultrasound safety: a narrative review of tissue heterogeneity challenges.Frontiers in medical technology · 2026Review
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Authors and funding
11 authors.
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Abstract
Nanodroplets have emerged as promising contrast agents due to their ability to undergo acoustic droplet vaporization (ADV), enabling size expansion for diverse biological applications such as selective contrast enhancement and localized drug delivery. While ADV has been widely utilized, the influence of acoustic parameters on its dynamics remains poorly understood, despite their potential to modulate ADV efficiency and uniformity, particularly with focused ultrasound (FUS). In this study, we developed a well-defined synthetic and characterization protocol for anionic perfluoropentane (PFP) nanodroplets and systematically investigated the effects of the pulse repetition frequency (PRF) and cycle number on ADV using acoustic signal detection and B-mode ultrasound imaging. In addition, we developed a modified acoustic-thermal model and simulation framework to elucidate the underlying mechanisms governing ADV behavior. Our findings reveal that increasing PRF and cycle number independently lowers ADV thresholds until reaching a saturation point, indicating that excessive ultrasound intensity is unnecessary. The acoustic conditions (PRF = 1000 Hz; cycle number = 175) were successfully applied
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