Evidence map›Paper›PMID 40522618›Full record

ArticleFrontiers of medicine2025

ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis.

Chengfang Zhang, Fei Li, Bao Chai, Jian Jiang, Yinlian Zhang, Xuemei Li, Jingyu Zhang, Yuqiong Huang, Zilin Jin, Yixuan Wang Wan and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Frontiers of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chengfang Zhang *Ningxia Medical University, Yinchuan, 750004, China.
Fei Li *Department of Cosmetic Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China.
Bao Chai *Department of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China.
Jian JiangDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yinlian ZhangShenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, 518055, China.
Xuemei LiDepartment of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China.
Jingyu ZhangDepartment of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China.
Yuqiong HuangDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zilin JinDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yixuan Wang WanDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Suwen LiuDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Nan YuDepartment of Dermatology, General Hospital of Ningxia Medical University, Yinchuan, 750004, China. 13895095009@163.com.
Hongxiang ChenDepartment of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. hongxiangchen@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory skin disease, and its pathogenesis is largely modulated by abnormal angiogenesis. Previous research has indicated that AlkB homolog 5 (ALKBH5), an important demethylase affecting N

Indexed as

AlkB Homolog 5, RNA DemethylaseNeovascularization, PathologicPsoriasisAngiogenesisAnimalsCell ProliferationDisease Models, AnimalHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMice, KnockoutProto-Oncogene Proteins c-aktSignal TransductionSkinAlkB Homolog 5, RNA DemethylasemTOR protein, mouseProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAKT/mTOR signaling pathwayALKBH5angiogenesism6Apsoriasis

Identifiers

PMID40522618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.