Evidence map›Paper›PMID 40522580›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

"Assessing relationship between blood MAPT methylation levels and clinical expression in Frontotemporal Dementia".

Gemma Lombardi, Silvia Bagnoli, Assunta Ingannato, Alice Finocchi, Silvia Campagnini, Silvia Fostinelli, Antonio Longobardi, Roberta Ghidoni, Giuliano Binetti, Barbara Borroni and 5 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gemma LombardiDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, viale Pieraccini 6, Florence, 50139, Italy. gemmalomb@gmail.com.ORCID http://orcid.org/0000-0003-2699-0359
Silvia BagnoliDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, viale Pieraccini 6, Florence, 50139, Italy.
Assunta IngannatoDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, viale Pieraccini 6, Florence, 50139, Italy.
Alice FinocchiIRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, Florence, 50143, Italy.
Silvia CampagniniIRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, Florence, 50143, Italy.
Silvia FostinelliMemory Clinic, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Via Pilastroni 4, Brescia, 25125, Italy.
Antonio LongobardiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Via Pilastroni 4, Brescia, 25125, Italy.
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Via Pilastroni 4, Brescia, 25125, Italy.
Giuliano BinettiMemory Clinic, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Via Pilastroni 4, Brescia, 25125, Italy.
Barbara BorroniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Via Pilastroni 4, Brescia, 25125, Italy.
Jasmine RivoltaDepartment of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, Brescia, 25121, Italy.
Sonia PadiglioniRegional Referral Centre for Relational Criticalities - Tuscany Region, Careggi University Hospital, Largo Brambilla 3, Florence, 50134, Italy.
Valentina BessiDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, viale Pieraccini 6, Florence, 50139, Italy.
Sandro SorbiDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, viale Pieraccini 6, Florence, 50139, Italy.
Benedetta NacmiasDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, viale Pieraccini 6, Florence, 50139, Italy.

Funding

Italian Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP) project MNESYS (PE0000006)Ministero della Salute RF-2018-12366665Ministero della Salute Ricerca Corrente 2023
6 · The paper itself

Abstract

introductionLittle is known regarding the relationship between methylation levels and Frontotemporal Dementia (FTD).

objectiveThe objective of the present study was to assess the relationship between blood MAPT methylation levels and clinical expression in FTD.

methodsThis cross-sectional observational study was conducted including 54 Italian patients with different phenotypes: 22 behavioral variant FTD (bvFTD), 10 semantic variant (svPPA), 22 non-fluent variant (nfv) Primary Progressive Aphasia (PPA).

resultsResults reveal a negative correlation between MAPT methylation levels determined by pyrosequencing analysis and the severity of disease in the FTD group and highlight an association between nfvPPA variant and intermediate-high levels of MAPT methylation, which persists also considering disease severity.

conclusionsOur findings allow us to speculate that the degree of MAPT methylation in the blood, a test minimally invasive, cost-effective, and easily repeatable could be useful to differentiate FTD variants at onset and to confirm disease stage in symptomatic FTD patients. Further studies, also with a longitudinal design, are warranted to confirm our results.

Indexed as

DNA MethylationFrontotemporal Dementiatau ProteinsAgedCross-Sectional StudiesFemaleHumansItalyMaleMiddle AgedSeverity of Illness IndexMAPT protein, humantau ProteinsBiomarkersEpigeneticsFrontotemporal dementiaMAPTMethylationPyrosequencing

Identifiers

PMID40522580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.