ArticleBrain imaging and behavior2025
Fatigue, monocyte activation, and degree centrality of the thalamus in post-menopausal women living with HIV.
Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Post-menopause is associated with chronic fatigue, inflammation, and aberrant brain connectivity, however there is a dearth of studies comparing these effects as a function of HIV. The current study investigated whether degree centrality of the thalamus mediates the effect of sCD14, a marker of monocyte activation, on fatigue and whether those parameters vary as a function of HIV-status. Resting-state functional connectivity MRI data, blood plasma, and self-report data were collected from 16 HIV + and 25 HIV- post-menopausal women. Analyses tested whether degree centrality of the thalamus, caudate, and right putamen mediated the relationship between sCD14 and fatigue. HIV-serostatus was then tested as a moderator. Compared to HIV-negative, HIV + women had higher levels of sCD14, t(34) = -3.85, p <.001, and lower thalamic degree centrality, t(33) = 2.17, p =.038. SCD14 predicted lower thalamic DC, b = -1.16, p =.035. Degree centrality predicted fatigue, b = -4.50, p =.03. Indirect and moderation effects were not significant. Monocyte activation is feature of chronic HIV-infection that impacts the number of thalamic connections to whole brain. The reduced thalamic degree centrality is associated with greater neurobiological vulnerability for fatigue after menopause.
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