ArticleThe Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology2025
Predictors of prognosis by cardiac magnetic resonance imaging in patients with idiopathic restrictive heart disease.
Article in The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRestrictive cardiomyopathy (RCM) is characterized by increased myocardial stiffness, impaired diastolic filling, and preserved systolic function until advanced stages. Cardiac magnetic resonance imaging (CMR) provides precise strain analysis and tissue characterization, yet its prognostic value in idiopathic RCM remains underexplored. This study aims to evaluate the prognostic significance of CMR parameters, particularly myocardial strain and late gadolinium enhancement (LGE), in predicting outcomes in patients with idiopathic RCM.
resultsPatients demonstrated moderately impaired strain values, with global longitudinal strain (GLS) measured at -10.59 ± 4.64% and global circumferential strain (GCS) at -14.50 ± 4.98%, while maintaining preserved biventricular ejection fractions. LGE was present in 40% of patients. A GLS value greater than -9.5% independently predicted mortality (odds ratio [OR]: 1.195, p = 0.044) and heart failure (HF) hospitalization (OR: 1.152, p = 0.013). Additionally, LGE emerged as a strong independent predictor of both mortality (OR: 6.340, p = 0.004) and HF hospitalization (OR: 4.654, p = 0.001).
conclusionsCMR is a valuable tool for prognostication in idiopathic RCM. GLS and LGE are independent predictors of adverse outcomes.
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