ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025
Safety of ventricular tachycardia ablation under deep sedation with propofol and fentanyl.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Anaesthetic Techniques for Cardiac Ablation-A Scoping Review.Acta anaesthesiologica Scandinavica · 2026Article
- Simplified propofol-based deep sedation by electrophysiologists: Safe and versatile for pulsed field and thermal ablation.Heart rhythm O2 · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no current standard of anaesthetic management for CA of VT. Data on VT ablation under deep sedation with propofol and fentanyl are limited.
objectiveThe aim was to evaluate the feasibility and safety of CA of VT under deep sedation with propofol and fentanyl.
methodsData from 134 procedures in 106 patients undergoing CA for VT under sedation with propofol and fentanyl were prospectively included. Three groups were defined and compared: group 1 (no VT induction, n=36); group 2 (induction of hemodynamically unstable VT, n=42), and group 3 (induction of hemodynamically stable VT, n=56).
resultsMedian age was 64 years, 84% were male, and 97% had structural heart disease. Group 2 had a higher proportion of patients with DCM (p=0.04) and severely reduced LVEF (p=0.024). Unipolar RF ablation was performed in 95% of procedures, bipolar in 12%, and alcohol ablation in 4%. Epicardial access was utilized in 18%. Radiation dose was higher in group 2 (p=0.04), while post-ablation non-inducibility was more frequently achieved in group 3 (p=0.045). There were no cases of profound hypotension or intubation associated with sedation. CPR was performed in seven procedures due to PEA, all in group 2 (p<0.001) with ROSC achieved in all cases within 3 min. No differences were observed in complication rates or hospital stay.
conclusionCA for VT under deep sedation with propofol and fentanyl in patients with structural heart disease is feasible and safe, irrespective of VT induction, mapping, and ablation approach. Hemodynamic instability, hypotension, and desaturation can be effectively managed.
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