Evidence map›Paper›PMID 40522487›Full record

SynthesisNeuroradiology2025

Prevalence of suboccipital and intradural vertebral artery variants: a systematic review with meta-analysis.

George Triantafyllou, Panagiotis Papadopoulos-Manoralarakis, Rǎzvan Costin Tudose, Mugurel Constantin Rusu, George Tsakotos, Maria Piagkou

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. The persistent proatlantal artery: types and subtypes.Surgical and radiologic anatomy : SRA · 2026
    Review
  3. Article
  4. Fenestrated giant mastoid emissary vein, a novel finding.Surgical and radiologic anatomy : SRA · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

George TriantafyllouDepartment of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis Papadopoulos-ManoralarakisDepartment of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Rǎzvan Costin TudoseDivision of Anatomy, Department 1, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Mugurel Constantin RusuDivision of Anatomy, Department 1, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
George TsakotosDepartment of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Maria PiagkouDepartment of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece. mapian@med.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe current systematic review, along with a meta-analysis, aims to present and calculate the pooled prevalence of the morphological variants of the vertebral artery (VA) within the suboccipital (V3) and intradural (V4) segments.

methodsAccording to the most recent guidelines, the systematic review was conducted using four online databases. Eligible studies were extracted, and a meta-analysis was performed utilizing R programming software. A subgroup analysis was conducted based on nationality and imaging techniques.

resultsThe systematic review revealed thirty-two (32) studies involving 176,391 patients. The pooled prevalence of VA fenestration was established at 0.30% (95% CI: 0.14–0.51). Furthermore, the persistent first intersegmental artery (PFIA) was estimated to have a pooled prevalence of 1.17% (95% CI: 0.36–2.34), wherein the imaging technique and nationality served as a significant moderator. An aberrant origin of the posterior inferior cerebellar artery from the V3 segment was identified, with a pooled prevalence of 2.69% (95% CI: 1.13–4.82). Additionally, the pooled VA dominance, hypoplasia, and atresia prevalences were recorded at 27.45%, 13.41%, and 5.39%, respectively.

conclusionsMagnetic resonance or computed tomography angiographies can accurately illustrate the distal VA’s diverse anatomical configurations. Specific variants hold substantial clinical significance, as they are correlated with posterior circulation cerebrovascular incidents and may complicate posterior approaches to the craniocervical region.

Indexed as

Vertebral ArteryHumansPrevalenceEvidence-based anatomyIntradural segmentMeta-analysisNeuroradiologySuboccipital segmentVariationVertebral artery

Identifiers

PMID40522487
PMCPMC12494658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.