Evidence map›Paper›PMID 40522466›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Native Ligand-Inspired peptides for c-MET targeted PET probes development.

Renli Luo, Boyu Tan, Ying Zhang, Jing Hu, Jia Lin, Luming Sun, Xiaonan Wei, Nianting Ju, Xiangning Luo, Chuan Chen and 9 more

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Renli LuoInstitute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang, 110167, China.
Boyu TanState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Ying ZhangState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Jing HuSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Jia LinSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Luming SunState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Xiaonan WeiState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Nianting JuState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Xiangning LuoState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Chuan ChenState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Junyu BaoState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Ji TaoState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Yanting QuState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Chunrong QuState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Renda LiInstitute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang, 110167, China.
Yuanpeng JiangState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Quanyong LuoDepartment of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200235, China. luoqy@sjtu.edu.cn.
Rui CaoDepartment of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200235, China. caorui_neu@163.com.
Zhen ChengSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. zcheng@simm.ac.cn.ORCID 0000-0001-8177-9463

Funding

Gansu Science and Technology Major Project 23ZDFA014National Natural Science Foundation of China U2267221 and 82472091Natural Science Foundation of Shanghai 24ZR1477300Ningbo Major Research and Development Plan Project 2024Z214Science and Technology Commission of Shanghai Municipality TM202301H003Shandong Laboratory Program SYS202205State Key Laboratory of Drug Research No. SIMM0120231004
6 · The paper itself

Abstract

purposeNative ligand-derived peptides have significantly advanced the development of targeting ligands in radiopharmaceutical discovery and design. Herein, we report the first attempt to develop novel mesenchymal-epithelial transition factor (c-MET) targeted peptide positron emission tomography (PET) probes based on the endogenous biomolecule, hepatocyte growth factor (HGF).

methodsThree c-MET targeted peptides were designed from the N-terminal and kringle 1 domain (NK1: 32-207 amino acid residues) of HGF. Then they were conjugated with chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and radiolabeled with [

resultsAmong three PET probes, [

conclusionA novel c-MET-targeting PET probe, [

Indexed as

PeptidesPositron-Emission TomographyProto-Oncogene Proteins c-metAnimalsCell Line, TumorGallium RadioisotopesHepatocyte Growth FactorHeterocyclic Compounds, 1-RingHumansLigandsMiceRadiopharmaceuticalsTissue Distribution1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidGallium RadioisotopesHepatocyte Growth FactorHeterocyclic Compounds, 1-RingLigandsPeptidesProto-Oncogene Proteins c-metRadiopharmaceuticalsC-METHGFNative ligandPeptide probesPET/CT imagingRadiopharmaceuticals

Identifiers

PMID40522466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.