Evidence map›Paper›PMID 40522453›Full record

ArticleAmerican journal of epidemiology2026

Pain during midlife: a cross-national analysis of cohort differences in reports of pain in the United States, Europe, South Korea, and Mexico.

Orchee L Syed, Frank J Infurna, Yesenia Cruz-Carrillo, Nutifafa E Y Dey, Markus Wettstein, Kevin J Grimm, Margie E Lachman, Denis Gerstorf

Abstract read
In one paragraph

Article in American journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Orchee L SyedDepartment of Psychology, Arizona State University, Tempe, AZ, United States.
Frank J InfurnaDepartment of Psychology, Arizona State University, Tempe, AZ, United States.ORCID 0000-0002-0690-9253
Yesenia Cruz-CarrilloDepartment of Psychology, Arizona State University, Tempe, AZ, United States.ORCID 0009-0008-1288-5535
Nutifafa E Y DeyDepartment of Psychology, Arizona State University, Tempe, AZ, United States.ORCID 0000-0003-4836-2644
Markus WettsteinDepartment of Psychology, Humboldt University, Berlin, Germany.ORCID 0000-0002-3471-5405
Kevin J GrimmDepartment of Psychology, Arizona State University, Tempe, AZ, United States.
Margie E LachmanDepartment of Psychology, Brandeis University, Waltham, MA, United States.ORCID 0000-0003-3027-8735
Denis GerstorfDepartment of Psychology, Humboldt University, Berlin, Germany.ORCID 0000-0002-2133-9498

Funding

Psychosocial Risk and Resilience Mechanisms Underlying Diversity in Midlife Health, Well-Being, and CognitionR01AG079523 · NIA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Frank John Infurna · 2022 to 2026
$2.5M
NIA NIH HHS R01 AG079523
6 · The paper itself

Abstract

Middle-aged Americans today are reporting poorer mental, cognitive, and physical health compared to previous cohorts, but this trend has not been consistently observed in other nations. It is an open question whether pain shows similar cohort differences among US middle-aged adults compared to other nations. We used harmonized data on pain from nationally representative longitudinal panel surveys from the United States, 13 European nations (England, Continental, Mediterranean, and Nordic regions), South Korea, and Mexico to directly quantify cohort similarities and differences in midlife pain. Results from multilevel models demonstrated that midlife pain is higher among later-born cohorts in the United States than among earlier-born cohorts. The increased odds for later-born cohorts emerged in the early years of midlife, when people are in their early 50s. A similar pattern of increased odds of reporting pain for later-born cohorts was observed in England and Mexico. In contrast, decreased odds of reporting pain for later-born cohorts were observed in Continental, Mediterranean, and Nordic Europe as well as South Korea. Results for pain severity revealed a highly similar pattern. Our discussion focuses on potential explanations, including population-level discrepancies in use and quality of healthcare services and how pain is conceptualized across nations. This article is part of a Special Collection on Cross-National Gerontology.

Indexed as

PainAdultAgedEuropeFemaleHumansLongitudinal StudiesMaleMexicoMiddle AgedRepublic of KoreaUnited Statescohort effectsglobal aginghistorical change in painlifespan developmentmidlifemultilevel modeling

Identifiers

PMID40522453
PMCPMC13334332

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.