Trial reportClinical oral investigations2025
Adjuvant effects of injectable platelet-rich fibrin (i-PRF) in the non-surgical periodontal therapy: a split-mouth randomized controlled clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Platelet-Rich Fibrin with Minocycline versus Arestin in Non-surgical Periodontal Therapy: A Split-Mouth Randomised Controlled Clinical Trial.Oral health & preventive dentistry · 2026Trial
- Comparative evaluation of microneedling-assisted injectable PRP versus PRP for managing thin gingival phenotype: A randomized clinical study.Bioinformation · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the impact of injectable platelet-rich fibrin (i-PRF) as an adjunct to scaling and root planing (SRP) in patients with periodontitis. MATERIALS AND
methodsTwenty-four patients, with two pairs of contralateral teeth (probing depth [PD] ≥ 5 mm), were enrolled. The tooth pairs were randomly assigned to either the control group (SRP, n = 149 sites) or the experimental group (SRP + i-PRF, n = 135 sites). The clinical parameters PD, gingival recession (GR), clinical attachment level (CAL), plaque index (PI), and full mouth bleeding on probing (fBOP) were evaluated at baseline and 45 and 90 days. Radiographic analysis measured the distance from the cementoenamel junction to the alveolar bone crest (CEJ-BC) at baseline and 90 days.
resultsBoth groups showed significant reductions in PD, CAL, fBOP, and PI from baseline to 45 days (p < 0.001), without significant differences between the groups (p > 0.05). The test group exhibited increased GR at 45 days (p < 0.05). CEJ-BC decreased in both groups at 90 days with no significant intergroup difference (p > 0.05). At 90 days, no significant intra- or intergroup differences were observed in any of the clinical parameters (p > 0.05).
conclusionSRP alone or combined with i-PRF resulted in comparable clinical and radiographic improvements in patients with periodontitis. Adjunctive i-PRF did not offer significant additional benefits. CLINICAL RELEVANCE: This study shows SRP alone and SRP + i-PRF yield satisfactory periodontal outcomes. Moreover, this study introduces the injection of i-PRF around the periodontal pocket, which, to the best of our knowledge, has not been extensively explored in the existing literature.
trial registrationhttps://ensaiosclinicos.gov.br/ : RBR-52h647m.
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