ArticleThe Journal of international medical research2025
Does diminished ovarian reserve impact oxidation-reduction potential in follicular fluid?
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A multidimensional follicular profile integrating oxidative stress, apoptosis and PI3K/AKT/mTOR signaling in relation to oocyte developmental competence in in vitro fertilization cycles.Journal of assisted reproduction and genetics · 2026Article
- Artificial Intelligence in Assessing Reproductive Aging: Role of Mitochondria, Oxidative Stress, and Telomere Biology.Diagnostics (Basel, Switzerland) · 2025Review
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Authors and funding
4 authors.
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Abstract
ObjectiveThis study aimed to evaluate oxidative stress in follicular fluid by measuring oxidation-reduction potential and determine its correlation with embryo quality in patients with diminished ovarian reserve.MethodsThis cross-sectional study included 134 patients with diminished ovarian reserve and 82 patients with normal ovarian reserve. Follicular fluid samples were collected from each patient via transvaginal aspiration under ultrasound guidance. Oxidation-reduction potential was measured using the Male Infertility Oxidative system, following the manufacturer's protocol.ResultsThe levels of anti-Müllerian hormone, number of oocytes retrieved, rate of blastocyst formation, and rate of high-quality embryos were significantly lower in the diminished ovarian reserve group than in the normal ovarian reserve group. Correlation analysis revealed that oxidation-reduction potential values had a negative correlation with the number of oocytes retrieved (r = -0.262, p = 0.002), rate of mature oocytes (r = -0.260, p = 0.002), and rate of normal fertilization (r = -0.207, p = 0.016); however, these values showed a positive correlation with the duration of ovarian stimulation (r = 0.186, p = 0.031).ConclusionsOxidative stress in follicular fluid correlates with a small number of oocytes retrieved, lower proportion of mature oocytes, and lower rate of normal fertilization in patients with diminished ovarian reserve.
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