ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
History of Breastfeeding in Relation to Circulating Inflammatory and Metabolic Biomarkers.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBreastfeeding history has been associated with reduced risk of chronic diseases, although the underlying biological link is unclear.
methodsThe study included 16,165 parous women in the Nurses' Health Studies who reported lactation history and biomarkers measured using plasma samples collected at midlife. We calculated multivariable-adjusted geometric means of 10 inflammatory biomarkers [high-sensitivity C-reactive protein, IL6, IL8, IL10, insulin-like growth factor 1 (IGF1), soluble TNFα receptor 2, B cell-activating factor, C-X-C motif chemokine ligand 13, soluble IL2 receptor α, and soluble IL6 receptor-α] and eight metabolic biomarkers (triglyceride, total cholesterol, high- and low-density lipoprotein, leptin, soluble leptin receptor, adiponectin, and retinol-binding protein 4) by the self-reported history of breastfeeding prior to blood collection. The FDR was used for multiple testing corrections.
resultsThe average age at blood collection was 52.6 years. Ever breastfeeding was associated with higher IGF1 (149.22 vs. 143.76 ng/mL; P value = 0.0002/FDR = 0.004) compared with never breastfeeding. Longer breastfeeding duration was associated with lower IL10 (P-trend = 0.001/FDR = 0.01) and higher IGF1 (P-trend = 0.0005/FDR = 0.01). No significant associations were observed for other biomarkers. Longer breastfeeding duration was associated with higher IGF1 among premenopausal women but not among postmenopausal women (P-interaction = 0.02). Longer breastfeeding duration was associated with lower soluble leptin receptor levels among those with body mass index ≥25 kg/m2 (P-trend = 0.01/FDR = 0.09) but not among those with body mass index <25 kg/m2 (P-interaction = 0.0002).
conclusionsEver breastfeeding and longer breastfeeding duration were associated with higher IGF1 levels measured in midlife. IMPACT: Our results support the potential long-term systemic impact of breastfeeding on circulating IGF1 levels, which may influence future chronic disease risk.
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