Evidence map›Paper›PMID 40522190›Full record

ArticleAdvanced healthcare materials2025

Magnetic-Driven Torque-Induced Electrical Stimulation for Millisecond-Scale Wireless Neuromodulation.

Chao-Chun Cheng, Li-Ling Chen, Guan-Jhong Tseng, Jun-Xuan Huang, Yen-Jing Ting, Po-Han Chiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chao-Chun ChengInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan(R.O.C.).
Li-Ling ChenInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan(R.O.C.).
Guan-Jhong TsengInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan(R.O.C.).
Jun-Xuan HuangInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan(R.O.C.).
Yen-Jing TingInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan(R.O.C.).
Po-Han ChiangInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan(R.O.C.).ORCID https://orcid.org/0000-0003-4100-4051

Funding

Academia SinicaNational Science and Technology Council
6 · The paper itself

Abstract

Wireless neuromodulation using nanoparticles, offering minimally invasive alternatives to conventional deep brain stimulation (DBS) while reducing the risks associated with hardware implants, has gained significant traction over the past decade. Nevertheless, ensuring millisecond-scale wireless DBS for the precise temporal control of neuronal activity remains challenging. This study reports magnetic-driven torque-induced electrical stimulation (MagTIES), a torque-based magnetoelectric neuromodulation method. By utilizing magnetic nanodiscs to generate torque under alternating magnetic fields (AMFs), the MagTIES induces a piezoelectric effect in piezoelectric nanoparticles, thereby overcoming the limitations of traditional magnetostriction-based systems. With an AMF (50 mT at ≈10 Hz), the proposed approach triggers neuronal activity both in vitro and in vivo, specifically in the deep brain region of the amygdala, within milliseconds. Furthermore, MagTIES enables the fine-tuning of amygdala brain oscillations through the precise modulation of the AMF frequency. By combining high spatial and temporal precision with minimal invasiveness, MagTIES provides an innovative approach for advancing neuroscience research with potential applications in understanding neural circuits and developing innovative therapies.

Indexed as

Deep Brain StimulationElectric StimulationWireless TechnologyAmygdalaAnimalsMagnetic FieldsMaleNeuronsRatsRats, Sprague-DawleyTorquebarium titanate nanoparticlesmagnetite nanodiscsmagnetoelectric stimulationmillisecond‐scale temporal precisionwireless neuromodulation

Identifiers

PMID40522190
PMCPMC12333473

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.