Evidence map›Paper›PMID 40522115›Full record

ArticleJournal of animal science2025

Effects of supplemental seaweed extract on antioxidant properties, loose stools, gut microbiota, and its metabolite composition in adult dogs.

Mingrui Zhang, Ruixia Mo, Yuankai Qu, Mingtan Li, Haotian Wang, Pan Liu, Tianyi Liu, Yi Wu

Abstract read
In one paragraph

Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. DietaryAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingrui ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Ruixia MoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yuankai QuShidai Marine Biotechnology Co., Ltd., Weihai, China.
Mingtan LiShidai Marine Biotechnology Co., Ltd., Weihai, China.
Haotian WangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Pan LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Tianyi LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yi WuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID 0000-0002-2105-8629

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to investigate the impact of seaweed extract (SWE) on the antioxidant properties, gut microbiota composition, and loose stools in adult dogs. A total of 30 Golden Retrievers were divided into three treatment groups. The dietary treatments administered were as follows: (1) healthy control: healthy dogs fed a basal diet; (2) loose stools control (LC): dogs with loose stools fed a basal diet; and (3) dogs with loose stools fed a basal diet supplemented with 20 g/kg SWE (LS), evenly top-dressed on the feed. The feeding trial lasted 28 d. Hematological analysis indicated that all dogs were healthy. Dietary supplementation with 2% SWE improved the loose stools of dogs compared to the LC group (P < 0.05). Dogs in the LS group had higher serum antioxidase activities and lower serum malondialdehyde concentrations compared to the LC group (P < 0.05). Meanwhile, serum levels of immunoglobulin A (IgA), IgM, and interleukin-10 (IL-10) were higher in the LS group than in the LC group (P < 0.05). However, serum levels of inflammatory markers (IL-1β, C-reactive protein, and tumor necrosis factor-α) and intestinal barrier markers (d-lactate, lipopolysaccharide, intestinal fatty acid-binding protein, and diamine oxidase) were lower in the LS group than in the LC group (P < 0.05). Furthermore, SWE increased SCFA-producing gut microbiota (especially Bifidobacterium and Holdemanella) abundance and fecal propionate concentrations (P < 0.05), probably contributing to its antioxidant properties. Conclusively, supplementing 2% SWE to the diet of dogs can improve antioxidant properties and reduce loose stools in dogs, accompanied by the alterations in gut microbiota and its metabolite composition. Our findings provide data and theoretical support for the effects and applications of SWE in canine nutrition.

Indexed as

AntioxidantsGastrointestinal MicrobiomePlant ExtractsSeaweedAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsDietDietary SupplementsDogsFecesFemaleMaleAntioxidantsPlant Extractsantioxidant propertiesdoggut microbiotaloose stoolsseaweed extractshort-chain fatty acids

Identifiers

PMID40522115
PMCPMC12168205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.